Conclusions: Response to initial statin dose predicts response to dose titration. Dose
titration of statins is therefore not an effective strategy to reach aggressive LDL goals in …

Ezetimibe is a lipid-lowering drug that inhibits the intestinal absorption of dietary and biliary
cholesterol by blocking passage across the intestinal wall. The efficacy and safety of adding …

Background—Despite the established efficacy of statins, many patients do not achieve
recommended LDL cholesterol (LDL-C) goals. Contributing factors may be inadequate …

Abstract Purpose of Review The Improved Reduction of Outcomes: Vytorin Efficacy
International Trial (IMPROVE-IT) demonstrated the clinical benefit of the combination of …

Background: Combining statins with ezetimibe synergistically enhances lipid lowering,
thereby reducing the need to prescribe maximal statin doses to achieve low-density …

Background A considerable number of patients with severely elevated LDL-C do not
achieve recommended treatment targets, despite treatment with statins. Adults at high …

Background: People with diabetes mellitus (DM) are at increased risk of coronary heart
disease (CHD). Previous primary prevention trials have involved too few people with DM to …

BARCELONA—Adding 10 mg/day of ezetimibe to maximum-dose rosuvastatin in a high-risk
population enabled 94% of patients to achieve an LDL level below 100 mg/dL and 80% to …

Study design This was a 6-week, prospective, randomized, open-label trial on patients
recruited from the practices of 241 Canadian general practitioners. Eligible patients signed …