摘要设计口服结肠靶向的递送系统对于治疗结肠有关的疾病非常重要, 因为这种方式能够使药物
精确施用到病变部位, 提高药物生物利用度和患者的顺应性. 尤其, 以纳米粒子为基础的口服制剂 …

口服结肠靶向给药系统由于能改善结肠局部疾病的治疗效果和降低不良反应而成为该领域的
研究热点. 口服给药系统设计方法的不断发展显著提高了药物在结肠部位的生物利用度, 然而 …

Colon-targeted oral delivery is crucial for the treatment of colon-related diseases, as this
delivery strategy enables precise drug administration to the diseased site, enhances drug …

Background: Targeting drug delivery is an attractive research area, as it enables localized
treatment, improves the efficacy of therapeutics and reduces systemic toxicity. Colon …

Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of
research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease …

The colon is the attractive target for the delivery of nano formulation due to distinct
advantages such as near-neutral pH, longer transit time, and reduced enzymatic activity …

纳米粒递送药物能提高药物在胃肠道中的稳定性, 增强药物在黏膜层的穿透,
是众多药剂工作者的研究热点. 然而, 目前的研究大多局限在其整体药效结果 …