Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the
mechanism is still unknown. The aim of the current study was to unravel the molecular …

Salsalate plays beneficial roles for ameliorating hyperglycemia and dyslipidemia in type 2
diabetes patients, but the underlying mechanisms are still poorly understood. In this study …

Background and aims: Low-grade chronic inflammation plays an important role in the
pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study …

Brown adipose tissue (BAT), an organ that burns energy through uncoupling thermogenesis,
is a promising therapeutic target for obesity. However, there are still no safe anti-obesity …

Sucralose is one of the most widely used artificial sweeteners used by the food industry to
reduce the calorie density of their products. Although broadly regarded as innocuous …

Background Brown adipose tissue (BAT) activation is a promising therapeutic target to treat
hyperlipidemia with obesity. Huang-Qi San (HQS), an traditional Chinese medicine, can …

Weight loss≥ 5 percent is sufficient to significantly reduce health risks for obese people;
therefore, development of novel weight loss compounds with reduced toxicity is urgently …

Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes
(T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the …

A safe and effective approach is needed to prevent and reduce the incidence of diabetes
worldwide. The hypoglycemic efficacy of salicylic acid (salsalate, SAL), which has anti …

Obesity is a risk factor for many chronic diseases related to the overexpansion of adipose
tissue during obesity, leading to metabolic dysfunction and ectopic lipids. Previous studies …