Aims and background Although glioblastomas infiltrate diffusely into adjacent brain, it is
difficult to unequivocally identify the solitary invading glioma cell. It is necessary to develop …

Purpose. The primary cause of local recurrence and therapeutic failure in the treatment of
malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it is …

Background The poor prognosis for glioblastoma patients is caused by the diffuse infiltrative
growth pattern of the tumor. Therefore, the molecular and cellular processes underlying cell …

OBJECTIVE: To develop an in vitro model under conditions that highly resemble the in vivo
situation for searching new therapeutics targeting invasive glioma cells. MATERIALS AND …

On radiograms, glial tumors are usually seen to invade in a finger-like fashion, while non-
central nervous system (CNS) tumors expand in a mass-like fashion. We prepared …

To simultaneously assess glioma cell invasion and glioma angiogenesis in vivo by non‐
invasive and quantitative means, DiI‐labeled C6 glioma spheroids were implanted into the …

To quantitatively analyze the spatial extent of glioma cell migration in an organotypic brain
slice culture, we developed a new invasion model with the aid of confocal laser scanning …

Aims Glioblastoma is the most frequent and malignant brain tumor. Recurrence is inevitable
and most likely connected to tumor invasion and presence of therapy resistant stem-like …

Glioblastoma (GBM) is the most common and lethal type of malignant primary brain tumor in
adults. GBM displays heterogeneous tumor cell population comprising glioma-initiating cells …

Background Recent studies have suggested that cancer stem cells cause tumor recurrence
based on their resistance to radiotherapy and chemotherapy. Although the highly invasive …