摘要建立合适的临床前研究模型是肿瘤研究转化的关键. 目前, 抗肿瘤药物的研究发展迅速,
但由于缺乏合适的临床前期研究模型, 大部分药物在进入Ⅱ 期临床试验前便夭折 …

Establishing an appropriate preclinical model is crucial for translational cancer research.
The most common way that has been adopted by far is grafting cancer cell lines, derived …

Development of novel drugs is an integral part of the translational medicine in the field of
cancer research, and the construction and application of preclinical animal models play vital …

摘要: 人源性肿瘤异种移植(PDX) 的小鼠模型使用至今已有近半个世纪的历史,
是肿瘤学研究领域中的重要工具之一. 与传统细胞株荷瘤小鼠模型不同的是, PDX …

Patient-derived tumor xenograft (PDX) models have a long history, starting with the first
mouse tumor xenograft model. However, continuously propagated cell lines and cell line …

Patient-derived xenograft (PDX) models for cancer research have recently attracted
considerable attention in both the academy and industry (Hidalgo et al., 2014; Wilding and …

The mouse models of nude mice bearing subcutaneous xenografts derived from tumor cell
lines provide a preclinical testing system for exploring novel anticancer therapies. However …

人体肿瘤PDX 移植模型的优与劣 实验动物科学 ›› 2015, Vol. 32 ›› Issue (05): 59-62. • 研究论著
• 上一篇 人体肿瘤PDX 移植模型的优与劣 1.( 1. 第四军医大学学员旅,西安710032) ( 2. 第四军医 …

Editorial Previously, cancer drug development was an arena that relied almost exclusively
on transgenic and severely compromised immuno-deficient (SCID) mice to measure tumor …

Recently, there has been an increasing interest in the development and characterization of
patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly …