黑色素生成是一种在黑色素细胞中产生黑色素的生物合成途径, 涉及一系列复杂的酶催化和化学
催化反应. 主要有5 条信号通路参与调控, 其中小眼相关转录因子(Microphthalmia-associated …

Melanogenesis is a biosynthetic pathway to produce melanin pigment in melanocyte,
involving a series of intricate enzymatic and chemical catalyzed reactions. Melanogenesis …

Melanogenesis, the intricate process of melanin synthesis, is central to skin pigmentation
and photoprotection and is regulated by various signaling pathways and transcription …

Tyrosinase and its transcriptional regulator microphthalmia-associated transcription factor
(MITF) play critical roles in regulation of melanogenesis, and are required for environmental …

In this study, we investigated the effects of lysophosphatidic acid (LPA) on melanogenesis in
Mel-Ab cells. We found that LPA significantly attenuates melanin synthesis, and reduces the …

Melanins are widely distributed in animals and plants; in vertebrates, most melanins are
present on the body surface. The diversity of pigmentation in vertebrates is mainly attributed …

Long-term topical skin care by traditional anti-melanogenic agents can raise several safety
concerns. An understanding of the molecular mechanisms of active compounds on …

Microphthalmia-associated transcription factor (MITF) is highly expressed in melanocytes
and is the main regulator of melanogenesis and melanocyte cell fate. Although MITF is …

Ultraviolet radiation exposure is a major cause of extrinsic skin aging, which leads to skin
hyperpigmentation. Loganin, a major iridoid glycoside obtained from Corni fructus, has anti …

Tyrosinase is a key enzyme for melanin biosynthesis, and hyperpigmentation disorders are
associated with abnormal accumulation of melanin pigments, which can be improved by …