Pharmacology and toxicology of Cannabis derivatives and endocannabinoid agonists

G Gerra, A Zaimovic, ML Gerra… - Recent Patents on …, 2010 - ingentaconnect.com
For centuries Cannabis sativa and cannabis extracts have been used in natural medicine.
Δ9-tetrahydrocannabinol (THC) is the main active ingredient of Cannabis. THC seems to be …

Cannabinoids, endogenous ligands and synthetic analogs

E Pop - Current opinion in chemical biology, 1999 - Elsevier
The investigation of natural and synthetic cannabinoid ligands, including (−)-Δ9-
tetrahydrocannabinol, cannabinol, cannabidiol, HU-210, HU-211, CT3, CP 55,940, WIN …

[PDF][PDF] The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in …

R Mechoulam, L Hanus - Pain Research and Management, 2001 - Wiley Online Library
The present paper describes the historical use of cannabis, starting with its use in Assyria
and China. Recent advances in the understanding of the molecular basis of cannabis action …

The therapeutic potential of the cannabinoids in neuroprotection

RI Grundy - Expert opinion on investigational drugs, 2002 - Taylor & Francis
After thousands of years of interest the last few decades have seen a huge increase in our
knowledge of the cannabinoids and their mode of action. Their potential as medical …

Cannabinoid pharmacology: the first 66 years

RG Pertwee - British journal of pharmacology, 2006 - Wiley Online Library
Research into the pharmacology of individual cannabinoids that began in the 1940s, several
decades after the presence of a cannabinoid was first detected in cannabis, is concisely …

[PDF][PDF] The multiple pathways of endocannabinoid metabolism: a zoom out

S Vandevoorde, DM Lambert - Chemistry & biodiversity, 2007 - Citeseer
Abbreviations.–AA, Arachidonic acid; AEA, arachidonoylethanolamide (anandamide); 2-AG,
2-arachidonoylglycerol; CNS, central nervous system; COX, cyclooxygenase; CRC …

Endocannabinoids in nervous system health and disease: the big picture in a nutshell

SD Skaper, V Di Marzo - Philosophical Transactions of …, 2012 - royalsocietypublishing.org
The psychoactive component of the cannabis resin and flowers, delta9-
tetrahydrocannabinol (THC), was first isolated in 1964, and at least 70 other structurally …

Potential therapeutic agents derived from the cannabinoid nucleus

HG Pars, JF Howes - Advances in drug research, 1977 - pubmed.ncbi.nlm.nih.gov
PIP: Drugs derived from Cannabis sativa (Cannabinceae) were used until the 1940's for
their stimulant and depressant effects for treating somatic and psychiatric illnesses …

[HTML][HTML] Themed issue on cannabinoids in biology and medicine

I Bab - British journal of pharmacology, 2011 - ncbi.nlm.nih.gov
Current cannabinoid research is based on a number of major discoveries made by
Professor Raphael Mechoulam. In the mid-1960s, he, together with Professor Yechiel Gaoni …

Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?

LE Filipiuc, DC Ababei, T Alexa-Stratulat, CV Pricope… - Pharmaceutics, 2021 - mdpi.com
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …