… targeting cell membrane gp96 promoted her2 ubiquitination and subsequent lysosomal …
degradation, and represents a new therapeutic strategy for inhibiting her2 signaling in cancer. …

… cancer are needed to provide a basis for treatment strategies targeting metastasis in patients
with breast cancer… be used in clinic for targeted therapy to curb tumorassociated lymphatic …

… attractive cancer therapeutic strategies. TCIs irreversibly bind to targeted proteins to …
On the other hand, PROTACs are able to accelerate targeted protein degradation. Moreover…

… terms of protein degradation, drug production, and treatment of … in the field of cancer treatment.
Using relevant development … as a strategy for in vivo target protein degradation. Science …

… well as the deregulation of protein degradation pathways like the … of tumor malignancy,
intervention strategies based on the key … degradation technologies such as proteolysis-targeting …

… ubiquitination of target proteins, directing them to the proteasome for … protein aggregates
and strategies to enhance ubiquitin driven protein degradation remain promising therapeutic …

… OSU03013 with better target selectivity in lung cancer. In … treatment of PHA665752 compound
and c-CBL WT protein expression would be the new therapeutic strategy for lung cancer…

… attractive cancer therapeutic strategies. TCIs irreversibly bind to targeted proteins to …
On the other hand, PROTACs are able to accelerate targeted protein degradation. Moreover…

… levels by occupancy drive, an in-creasing number of protein degradation … modulate protein
levels by degrading target proteins, and their emergence offers potential strategies for the treat…

… cancer. Currently, small-molecule inhibitors that target specific proteins are widely used in
tumor therapy. … to drug resistance, limited range of target proteins, and high toxicity, which limit …