Several studies have reported the beneficial effects of Lawsonia inermis on wound healing,
but the mechanism of action is still unknown. This study aimed to investigate the
effectiveness of a new ointment formulation of hydroethanolic extract leaves of L. inermis on
wound healing by gene expression of glucose transporter‐1 (Glut‐1) and insulin‐like growth
factor I (Igf‐1) in Wistar rats. The animals were topically treated with different doses of L.
inermis. An experimentally induced circular excisional wound model of 314 mm2 surface …

We investigated the wound healing effects of an ointment prepared from a hydroethanolic
extract of Trifolium pratense (red clover) in Wistar rats. An animal model was prepared by
making 314 mm2 full thickness skin excisions in all animals. Rats were divided into four
experimental groups. Group 1 was a non-intervention control. Groups 2, 3 and 4 were
treated topically with ointments containing 1.5, 3.0 and 6%(w/v) T. pretense extract,
respectively. We evaluated the effects of these ointments by histological analysis of collagen …