… The transient hIAPP oliomers might be toxic and have implicated in the islet β-cell apoptosis
and dysfunction. Islet amyloid deposits dominantly compromising of hIAPP fibrils may be …

… Type 2 diabetes is characterized by insulin resistance and insufficient insulin secretion from
… the balance of β-cell survival and death, resulting in β-cell dysfunction and deficiency. First, …

… resistance instead of insulin deficiency. Thus, the glucose-dependent promotion of insulin
secretion by DPP-4 inhibitors via improvement in pancreatic β-cell function may be particularly …

… pancreatic sections from patients with type 2 diabetes (T2D), … that T2D is characterized by a
deficit in β-cell mass.5-7 In the … study,5 namely that β-cell apoptosis increased significantly in …

… studies, vitamin D deficiency is now regarded as a potential risk factor for Type … Elevated
levels of pro-inflammatory cytokines may impair β-cell function by triggering β-cell apoptosis. …

… of β cells and insulin deficiency. Under insulin-resistant … of pancreatic β cell function and
mass, and finally Type 2 diabetes. … cellular ATP content and reduced pancreatic β cell apoptosis …

… of regulation of β-cell exocytosis and proliferation, and its relevance to type 2 diabetes, …
either type 1 or type 2 diabetes (T1D and T2D, respectively).63, 70, 71 As such, enhancing …

… Type 2 diabetes, the most common form of diabetes, affects hundreds of million people … ,
generating intracellular amyloid deposits that cause β-cell dysfunction and death. It is now clear …

… and relative insulin deficiency. In … higher levels of mature miRNA levels.25 Therefore, the
variant allele A of rs72631823 contributes to increased β-cell apoptosis probably by increasing …

… of diabetes and it may account for at least approximately 1 %–2 % of all cases with type 2
diabetes (… decay resulting in insulin production deficiency and diabetes without β-cell death.25 …