ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S …
T Ishikawa, M Müller, C Klünemann, T Schaub… - Journal of Biological …, 1990 - ASBMB
The liver is the major organ which eliminates leukotriene C4 (LTC4) and other cysteinyl
leukotrienes from the blood circulation into bile. Transport of LTC4 was studied using inside-
out vesicles enriched in canalicular and sinusoidal membranes from rat liver. The incubation
of canalicular membrane vesicles with [3H] LTC4 in the presence of ATP resulted in an
uptake of LTC4 into vesicles. The initial rate of ATP-stimulated LTC4 uptake was about 40-
fold higher in canalicular than in sinusoidal membrane vesicles. When liver plasma …
leukotrienes from the blood circulation into bile. Transport of LTC4 was studied using inside-
out vesicles enriched in canalicular and sinusoidal membranes from rat liver. The incubation
of canalicular membrane vesicles with [3H] LTC4 in the presence of ATP resulted in an
uptake of LTC4 into vesicles. The initial rate of ATP-stimulated LTC4 uptake was about 40-
fold higher in canalicular than in sinusoidal membrane vesicles. When liver plasma …
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