Alzheimer’s disease (AD) is one of the most serious threats to human health, especially in
aged societies. Currently fundamental medical method is lacking to stop AD pathology of …

… 胆碱酯酶抑制剂( cholinesterase inhibitor, ChEI) 中毒造成的严重循环衰竭是一种恶性循环,
突出特 点是对大多数药物, 特别是升压药物失去反应.但 研究表明此时血管本身对药物反应仍良好[ …

… However, an effect of acetylcholinesterase inhibitors on plaque formation, although
previously speculated, had not been systematically investigated. Our recent work indicates that …

目的观察新型抗毒剂宾赛克嗪对维埃克斯染毒后不同时间点小鼠血浆内毒素浓度变化的影响及
其机制. 方法306 只雄性昆明小鼠被随机分为正常对照组, 维埃克斯染毒模型组以及宾赛克嗪, …

… Patients of AD are identified as having lower levels of Acetylcholine (Ach). Cholinesterase
inhibitors increase the levels of Ach, by inhibiting the breakdown of acetylcholine in the …

… , galantamine and rivastigmine are cholinesterase inhibitors. Memantine acts on the … of
donepezil (a cholinesterase inhibitor) with memantine. Delivery of these drugs to the brain is …

… toxicity with a willingness to allow organic chemistry alterations and some desirable properties
on his own, cholinesterase inhibition … With respect to cholinesterase inhibition, it appears …

… 酯酶抑制剂(acetylcholinesterase inhibitor, AChEI)高通量筛选模型并对其进行评价,检测97
个灵芝(Ganoderma lucidum)子实体醇提物对乙酰胆碱 酯酶(acetylcholinesterase,AChE)的抑制…

… 英文摘要 phencynonate hydrochloride (PCH) and penehyclidine hydrochloride(PH) are
novel anti-cholinerigic drugs invented by the Institute of Pharmacology and Toxicology, AMMS. …

… for Alzheimer’s disease are cholinesterase and β-secretase enzymes. In this review, we
discuss recent advances in profiling single target inhibitors based on these enzymes to …