[PDF][PDF] 钙蛋白酶-钙神经素通路和阿尔茨海默病

张艳, 李倩倩, 张黎明 - 中国现代神经疾病杂志, 2010 - cjcnn.org
Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP
transgenic mice. Neurobiol Learn Mem, 2007, 88:217⁃224. Liu F, Grundke ⁃ Iqbal I, Iqbal K, et …

阿尔茨海默氏病的病理机制和治疗策略

Y Ju, KY Tam - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
… -dependent phosphatase calcineurin, protein phosphatase 1 or … Restoration of serotonergic
function by selective serotonin … neuropathology in the triple-transgenic Alzheimer’s disease …

[PDF][PDF] 5× FAD 转基因小鼠在阿尔茨海默病研究中的应用进展

刘怡端, 刘翼骁, 韩欣园, 肖依彤… - 中国实验动物学报, 2024 - zgbjyx.cnjournals.com
… for the application of 5 × FAD transgenic transgenic mice in AD research. [… Learn Mem,
2008, 15(9): 625-632. [17] MORGAN D. Learning and memory deficits in APP transgenic

靶向tau 治疗阿尔茨海默病: 从机制到临床

J Ye, H Wan, S Chen, GP Liu - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
inhibition of CDK5 reduces tau phosphorylation and related neurodegeneration in transgenic
… Active and passive Aβ immunotherapies exhibit benefits in APP transgenic models. …

星形胶质细胞在阿尔茨海默病β 淀粉样蛋白损伤后血脑屏障破坏中的新作用

Q Yue, MPM Hoi - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… with familial AD, such as the mouse models Tg2576, 5×FAD, APP/ PS1, and 3×Tg-AD. All
these transgenic mouse models develop AD pathology including APP overproduction and Aβ …

谷氨酸功能异常与阿尔茨海默病

张帅, 艾静 - 神经药理学报, 2018 - actanp.hebeinu.edu.cn
… GluN2B 亚基的NMDA 受体介导的钙离子内流增加, 还会激活下游信号通路如Rap-p38-MAPK,蛋白
磷酸酶 PP1,calcineurin.PP1 可通过脱磷酸化激活GSK3β, 同时影响Caspase-Akt 通路,促进…