… inform the design of biologics aimed at targeting the PI3K/Akt … Given the limitations of current
T1D therapies, it is crucial to … cytotoxic effects of the pro-inflammatory cytokines (IL-1β, tumor …

… such as recombinant anti-inflammatory cytokines, cytokine receptors … clinical use of the
biologics targeting TNF-α, IL-1, IL-6 and IL-17, and point out their inherent limitations and clinical …

… inflammatory cytokines, mRNAs, and proteins involved in photoreceptor degeneration pathways
to exert a therapeutic … COX-2 inflammatory-related genes, as well as targeted genes that …

… due to pro-inflammatory cytokine signaling cascades that act … Generalized immunosuppression
may limit secondary tissue … of naturally derived biologic factors are emerging as potential, …

… is impeded by fundamental limitations. The key biological … invasive technology to supply
circulating biologics to the brain, … ) upregulation of proinflammatory cytokines (eg TNFα, IL1α, …

… targets and difficulties in identification of intracellular TAAs and CAR-T homing limit the
application … the US FDA Center in 1991 for biological products evaluation and research, the FDA …

… linked to certain limitations. Various types … target the brain lesions without the need for
bioactive agents to cross the blood-brain barrier, initially led to the injection of drugs and biologics …

… The purpose of this review is to explore what problems in … the secretion of proinflammatory
cytokines from distinct cell types. … now known for pleiotropic biologic properties in immunology …

… Besides that, therapeutic targeting of the CNS has been … A limitation of our studies is
the use of different mouse models, … its limitations. A cuprizone chow diet induces toxin-mediated …

… the pro-inflammatory/anti-inflammatory cytokines and chemokines. In … Finally, we discuss
the limitations of current research and the … in SAH will enable new targets and modulators to be …