… Methods BMSCs were extracted by whole bone marrow … aging of BMSCs, and drug
intervention was performed for 48 h. SA-β-galactosidase staining was used to detect cell senescence…

… senescence-accelerated mouse-P6) is an accelerated aging mouse with increased bone loss
with age and is suitable for elderly osteoporosis … The animal model of disuse osteoporosis …

… with aging,senescent cellsin the bone nicroenvironmentincrease,which can produce
senescence-… Cellular senescence in agingandage-relaled disease:from mechanisms lo herapy …

… as inhibit cell senescence through promoting the expression of Sirt1, PRC1/2 and cell cycle-…
and inducible nitric oxide synthase, lower the bone loss, increase the expression of alkaline …

… BM-MSCs application in cell therapy. Therefore, research in BM-MSCs senescence is of
great importance for the prevention and treatment of aging-associated bone tissue degenerative …

… regulatory mode of cell death, which plays an important role in bone aging. It … bone aging
from the above five aspects, providing new ideas for prevention and treatment of bone aging …

… feature of cellular senescence and plays an … bone metabolism and inducing bone loss is
very limited. Therefore,this paper discusses the regulatory mechanism of SASP in osteoporosis …

… Olaparib was used to maintain the telomere length and the role of telomere length and
senescence on the cell proliferation and … mass and physical activity in bone health in children[J]. J …

… the initiation and development of senescence and aging in mammals with several well-…
-coding RNAs in cellular processes, including cellular senescence, aging, and age-related …

… Oxidative stress can cause bone remodeling imbalance,and eventually can lead to osteoporosis.
Of these,aging, estrogen deficiency,FoxO transcription factor and Nox subtype all have …