… of a high quality chemical probe and the strategies to target USPs. … was discovered in
proteasome-mediated protein … represents positive charges and red for nega⁃ tive charges. The …

… were constructed following target binding relationships, … to eight miRNAs, further targeting
77 mRNAs; while eight … , ubiquitin-mediated proteolysis, proteasome and biosynthesis of …

… LYTAC Target to extracellular and transmembrane proteins; independent of ubiquitination
and proteasomal … AUTAC Potentially a broad target spectrum; proteasome independent; …

… Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer
therapies[J]. J Clin Oncol, 2013, 31(9): 1231-8. [4] Rieser E, Cordier SM, Walczak H. …

… a long diffusion distance to the target cells. Second, the vector … Finally, in the target cell
the vector is prone to proteasome … degradation by intracellular proteasomes. Furthermore, …

… CHIP 蛋白是一个二聚的E3 泛素连接 酶,主要有3 个功能结构域,分别为位于N 端的TPR 结构
域,中间的Charge 结构域和C 端的U-box 结构 域[1]. 其中,TPR 结构域负责与分子伴侣相结合,辅助 …

… , through the coordination of Parkin, a key regulator of mitochondrial function and dynamics,
the UPR can induce mitophagy (a major subtype of autophagy that selectively targets …

… This typically targets the substrate for degradation by the proteasome. … (C) The unusual
ubiquitin E3 ligase MYCBP2 binds a ubiquitin-charged E2 enzyme via its RING domain. The …

… NBR1-mediated selective autophagy targets insoluble ubiquitinated protein aggregates
in plant … Autophagic degradation of the 26S proteasome is mediated by the dual ATG8/ubiquitin …

… protein is targeted to the proteasome and degraded. Once the protein is in the proteasome,
… cuts some specific microRNAs that are in charge of repressing the translation of the pro-…