… response to clopidogrel appear to be at increased risk for cardiovascular events. Clopidogrel
is a prodrug that requires biotransformation to an active metabolite by cytochrome P-450 (…

Cytochrome P-450 polymorphisms and response to clopidogrel. - Abstract - Europe PMC …
Cytochrome P-450 polymorphisms and response to clopidogrel. … This is a comment on "Cytochrome …

… may be associated with cytochrome P-450 2C19*2 polymorphism - … responsiveness to
clopidogrel in the Japanese population, while we do not consider the CYP2C19 polymorphism …

… infarction (MI) treated with clopidogrel are unknown. … polymorphisms (SNPs) in selected
cytochrome P (CYP) genes with plasma concentrations of the active metabolite of clopidogrel …

… functional polymorphisms have been found in genes encoding cytochrome P-450 isoforms
involved in clopidogrel … response to clopidogrel has not been systematically investigated. …

… patients treated with standard clopidogrel doses do not respond properly and show low …
response and adverse reactions can be affected by polymorphic nature of the cytochrome P-450 …

… Clopidogrel requires transformation into an active form by cytochrome P-450 (CYP) enzymes
for its antiplatelet effect. Genetic polymorphisms of these enzymes have been implicated to …

… is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006; 108:
… Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360: …

… Clopidogrel is a prodrug which requires two-step activation through oxidative metabolism,
involving various cytochrome P-450 … of genetic polymorphisms of cytochrome P450(s) [10]. …

… The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its
antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, …