… a critical role for DNA methylation in developmental gene regulation. … DNA methylation in
mammalian cells. 5 In this review, we will discuss the fundamental aspects of DNA methylation …

… cells develop a stable and unique DNA methylation pattern that regulates tissue-… of
DNA methylation and demethylation in the nervous system. We will describe the DNA (de)methylation …

… Because DNA methylation is reversible, drugs like 5′-azacytidine, … DNA methyl transferase
and small interference RNA are being developed, making the field of DNA methylation …

… Moreover, unlike genetic alterations, DNA methylation is reversible what … DNA methylation
alterations in tumorigenesis encourages us to decode the human epigenome. Different DNA …

… DNA was noted over 40 years ago, its role in the regulation of gene activity has become
apparent only recently (8, 12, 13, 62). The first indications that DNA methylation … by methylation …

… of DNA methylation, studies of which have provided insights into how DNA methylation …
rise to the diverse array of defective DNA methylation patterns in human diseases. It should …

… methylation have identified numerous regions in which it is dynamically regulated. In this
Review, we discuss key concepts in the function of DNA methylation in … where DNA methylation …

The above experiments support a relatively simple model to explain the role of DNA methylation
in vivo. Most tissue-specific genes are methylated. The methyl groups may generate a …

… complex with the DNA, resulting in a progressive loss of DNA methylation with each round …
extremely valuable in studying the role of DNA methylation in gene expression. Treatment of a …

… In this article, we first summarize the basics of DNA methylation in the genome and … methylation
machinery and its role in development. We also discuss the functions of DNA methylation …