表观遗传调控在阿尔茨海默病相关认知功能障碍中的作用

曾伟, 罗佛全 - 神经损伤功能重建, 2024 - sjssygncj.chmed.net
… Key mechanisms of epigenetic regulation, including histone modification, DNA methylation,
… their interaction regulates cognitive function. This review focuses on Alzheimer's disease (AD…

淀粉样蛋白-β 介导的阿尔茨海默病病理生理学靶向表观遗传学机制: 揭示治疗潜力

JZ Li, N Ramalingam, S Li - 中国神经再生研究(英文版), 2025 - sjzsyj.com.cn
genetic and environmental factors. The memory and … and mild cognitive impairment phases
of Alzheimer’s disease are … machinery, specifically DNA methylation, histone modification, …

天然膳食化合物作为抗阿尔茨海默病药物的遗传和表观遗传靶标

WO Castillo-Ordoñez, N Cajas-Salazar… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
… effect of lifestyle on cognition varies by genetic dementia risk … can control gene expression
by deleting DNA methylation at … fluid biomarkers of Alzheimer disease. JAMA Neurol 72:699-…

揭示阿尔茨海默病中的DNA 甲基化: 基于阵列的人脑研究综述

VC Alves, E Carro, J Figueiro-Silva - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… The intricacies of Alzheimer’s disease pathogenesis are … whole genome DNA methylation
in Alzheimer’s diseasedisorder characterized by progressive cognitive and behavioral …

由内含子保留引起的Tau 截断在阿尔茨海默病皮质中富集并表现出改变的生化特性

CT Ong - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Cognitive decline in AD due to neuronal and synaptic loss is caused by the complex interplay
between pathological … co-regulated by the level of DNA methylation. For instance, during …

组织蛋白酶L 在阿尔茨海默病核层病变诱导中的调节作用

MI Islam, E Eftekharpour - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
DNA hypermethylation is suggested to be responsible for … of nuclear events and abnormal
gene expression and not the … amyloid pathology and improves cognition in an Alzheimer’s …

神经退行性疾病表观遗传学研究中因果关系评估的观点

P Koulousakis, A Tiane, N Hellings… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
DNA methylation refers to the process of adding methyl … for patients and care-takers due
to rapid cognitive decline. To … as a consequence of its pathophysiology. Secondly, it also has …

衰老相关神经退行性疾病的个性化干细胞模型研究进展

M Weng, R Jauch - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… sensation, memory, and cognition, which can ultimately lead … representing the pathophysiology
of human diseases and the … such as DNA methylation, global gene expression profiles, …

[PDF][PDF] 神经认知障碍临床人群中RNA 修饰系统的失调

HM Knight, MD Öz… - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… psychiatric disorders including conditions with clear cognitive deficits. … the current evidence,
ranging from genetic, RNA, and protein … in the pathogenesis of neurodegenerative diseases. …

DNA 甲基转移酶1 调节神经元的存活

J Symmank, G Zimmer - 中国神经再生研究(英文版), 2017 - sjzsyj.com.cn
… by DNA methylation in cortical interneurons in disease-… interneurons likely contributes to the
cognitive decline and somato-… Moreover, in patients diagnosed with Alzheimers disease, an …