… the LTP and LTD in CA1 region of the hippocampus. The predominant hypothesis is that the
… brain cortical cerebrospinal fluid acetylcholine levels were significantly lower in AD patients, …

… septum innervate the cerebral cortex and the hippocampus, respectively, … A phase 3 program
called cognitive Alzheimer's disease is … Basal dendritic size and complexity are low and …

… barrier in vivo, and a good in silico safety profile being less … and gliosis in the cortex and
hippocampus. A significant … astrogliosis in mouse models of Alzheimer disease. PLoS One 7:…

… than amyloid load with cognitive decline. The recent acceleration … deficits of their hippocampal
and cortical target neurons. … cognitive impairment and Alzheimer disease. J Neuropathol …

… ) was investigated in the cerebral cortex and hippocampus of … (ChAT) was significantly
reduced at 12 weeks of duration … ,尤其是阿尔茨海默病(Alzheimer disease , AD) 关系密切.但糖尿病…

… bind sigma1 receptors with high affinity at a low nanomolar range in vitro and behave as an
effective sigma1 receptor … mixed ligand for sigma1 and muscarinic receptors. The compound …

… muscarinic receptors are G-protein coupled receptors, … and rat hippocampal cultures provided
with PNU-120596 had … designed to have reduced side effect profiles, with less effect on …

… Cognitive decline in Alzheimer’s disease correlates with the … related regions of the brain
including the hippocampus. Recent … muscarinic (M1 and M3) subunits of acetylcholine receptors …

… , 是造 成阿尔茨海默病( Alzheimer disease, AD) 记忆缺失的 重要病理… -1 ) obviously decreased
the number of errors in five minutes … of muscarinic receptor in the cortex and hippocampus . …

… of receptors divided into two main groups, muscarinic and … the highest binding in cortical and
thalamic brain regions which … This work demonstrated lower values of adhesion molecules, …