[PDF][PDF] 靶向鞘氨醇激酶信号通路: 一种治疗血液肿瘤的新策略

王立生, 王华 - 中国药理学与毒理学杂志, 2015 - cjpt.magtechjournal.com
… ThepotentialandprospectoftargetingS1Pmetabolism and signaling in the development
BCR-ABL1 protein stability. SphK/ S1P signaling inhibits proteasomal degradation of BCR-ABL1

[HTML][HTML] 儿童Ph-like 急性淋巴细胞白血病的研究进展

唐雪, 郭霞 - Chinese Journal of Contemporary Pediatrics, 2017 - ncbi.nlm.nih.gov
… to lymphatic development. Children with Ph-like ALL account for 15% of children with high-…
学分型不明的B-ALL患儿基因表达谱与BCR-ABL1阳性ALL患儿相似,预后也与其相似,将其称…

[PDF][PDF] 高光谱相干拉曼散射技术及其应用

吴凡, 李商羽, 洪维礼, 岳蜀华, 王璞 - Laser & Optoelectronics …, 2022 - researching.cn
… Raman scattering technology has greatly promoted the development … (a) Representative
SRS images of BaF3/BCRABL1 cells … Quantitative chemical imaging and unsupervised analysis

[HTML][HTML] 嵌合抗原受体T 细胞序贯异基因造血干细胞移植治疗Ph 样急性淋巴细胞白血病21 例的疗效及安全性

戴海萍, 沈宏杰, 李正, 崔巍, 崔庆亚… - Chinese Journal of …, 2024 - ncbi.nlm.nih.gov
… Ph样急性淋巴细胞白血病(ALL)是一类特殊亚型的急性B淋巴细胞白血病(B-ALL),缺乏经典
BCR::ABL1融合基因,但和Ph/BCR::ABL1阳性ALL有高度类似的表达谱特征[1]。Ph样ALL在各…

急性髓细胞白血病的分子分型

王舒, 陈冰 - 上海交通大学学报(医学版), 2016 - xuebao.shsmu.edu.cn
… , and high throughput sequencing, the development of typing and prognosis evaluation system
… 突变,伴有BCR-ABL1 融合基因等新分 子亚型分类.在AML 诊断中,明确列出需进行突变检测 …

正常组织与肿瘤组织中总体5hmC 和5mC 水平的变化程度与结直肠癌肿瘤发生及预后有关

Y Tian, A Lin, M Gan, H Wang, D Yu, C Lai… - Journal of Zhejiang …, 2017 - Springer
… In this study, we used ELISA to quantify the genomewide 5hmC and 5mC levels because
of its convenience, cost-effectiveness, and relatively high sensitivity and specificity (Jin et al., …

[HTML][HTML] 第三代测序技术的研究进展与临床应用

谭聃, 欧铜 - 生物工程学报, 2022 - cjb.ijournals.cn
… techniques have been further developed, and have gradually … 1 Quantitative studies based
on the second-generation and … 其中约有25%–50%患者bcr-abl1激酶结构域突变,且在疾病的…

生长阻滞特异性转录因子5 剪接变异体GAS5_O1 增强慢性髓系白血病细胞对伊马替尼的敏感性.

张斯玮 - Chinese Journal of Biochemistry & Molecular …, 2024 - search.ebscohost.com
… 色体(Ph)和BCRABL1 融合基因是CML 的特征. 表达的促癌蛋白质BCRABL1具有高酪氨酸
激酶活 性,可激活不同的信号通路,抑制CML细胞凋亡和 促进其增殖[2]. 伊马替尼(imatinib,IM)仍是…

骨髓增殖性肿瘤出血并发症的危险因素及防治措施

黄丽颖, 张磊 - 临床血液学杂志, 2020 - lcxy.whuhzzs.com
… complications in newly diagnosed MPN patients is as high as 6.2%.The causes of bleeding
in … Contemporary management of patients with BCR-ABL1-negative myeloproliferative …

[PDF][PDF] 骨髓增生异常综合征中相关微小RNA 的研究进展

张惠桃, 肖鸿文, 李晓明 - 现代生物医学进展, 2018 - biomed.cnjournals.com
… plays an important role in the occurrence, development and prognosis of MDS. This article
… -203 的去甲基化是伊马替尼诱导的BCR-ABL1 阳性白血病细胞抑 制的分子机制之一. 7 种血浆…