[PDF][PDF] 聚焦基因治疗的扩张型心肌病模型构建及进展

陈玉林, 蒋虎刚, 安涛, 李雯, 严春艳, 黄倩… - 中国实验动物 …, 2023 - zgbjyx.cnjournals.com
… of hereditary dilated cardiomyopathy with LMNA mutation. In … large animal models of dilated
cardiomyopathy at the genetic level … efficacy to reverse cardiac hypertrophy and heart failure

中国汉族特发性扩张型心肌病患者LDB3 基因多态性与临床表现及植入型心律转复除颤器(ICD) 植入的相关性研究

D Wang, JL Lyu, J Fang, J Chen, WW Chen… - Journal of Zhejiang …, 2019 - Springer
Mutations in LIM domain binding 3 (LDB3) gene cause idiopathic dilated cardiomyopathy
(IDCM), a structural heart disease with a complicated genetic background. However, the …

诱导性多能干细胞联合基因编辑技术在遗传性心脏病研究中的应用进展

张莹 - 药学进展, 2023 - pps.cpu.edu.cn
… 3.6 iPSC 与CRISPR/Cas9 技术在DCM 研究中的应用 受磷蛋白(phospholamban,PLN)是定位
在… line (WAe009-A-70) to model dilated cardiomyopathy and arrhythmogenic right ventricular

[HTML][HTML] RNA 结合基序蛋白20 在心肌病中作用的研究进展

杨珍, 刘宇宁, 余薇, 郑萍 - 2019 - html.rhhz.net
… , which ultimately leads to heart failure even death. RNA-… ,是通过对其底物受磷蛋白(phospholamban,PLB),RyR和
L型Ca 2+ … mutations induce an arrhythmogenic dilated cardiomyopathy

From mouse to man, from gene to cl inic: Progress in heart researchusing genetically modif ied mouse models/基因修饰小鼠应用于心脏研究的进展: 从小鼠到人类, 从 …

X Du - Xi'an jiao tong da xue xue bao. Yi xue ban, 2008 - search.proquest.com
heart disease , such as heart failure. A : Depicted are two strains of genetically modified mice
with cardiac phenotypes of ei2 ther cardiomyopathy and heart … 受磷蛋白(phospholamban) ,…

NRIP 缺陷小鼠造成心室肥大

林思瑜 - 2012 - tdr.lib.ntu.edu.tw
… According to recent studies, mutations or deletions of … the process of cardiac hypertrophy to
dilated cardiomyopathy. By … in sarcoplasmic reticulum gene expression in human heart failure

[HTML][HTML] 钙/钙调蛋白依赖性蛋白激酶Ⅱ 抑制剂KN-93 加重大鼠离体心脏钙超载损伤

孔令恒, 顾晓明, 南瑛, 张建英, 孙娜, 朱娟霞, 周京军 - 2016 - html.rhhz.net
… Role of dual-site phospholamban phosphorylation in the stunned heart: insights from
phospholamban site-specific mutants[J]. Am J Physiol Heart Circ Physiol, 2003, 285 (3) : H1198-…

[HTML][HTML] ASB14 通过调控泛素化介导的线粒体自噬改善小鼠心力衰竭

王澈, 杨宏辉, 李庆民, 杜秋波, 朱利杰, 李清曼… - 中国医科大学 …, 2020 - html.rhhz.net
… model of heart failure was established by narrowing the thoracic aorta. The heart function
and … The ubiquitin proteasome system in human cardiomyopathies and heart failure[J]. Am J …

人诱导性多潜能干细胞建立心肌细胞疾病模型的研究进展

崔宁, 李蕾, 崔鸣, 兰峰 - 基础医学与临床, 2017 - journal11.magtechjournal.com
mutations in iPS cells define sarcomere insufficiency as a cause of dilated
cardiomyopathy [… Correction of human phospholamban R14del mutation associated …