Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute
substantially to ADHD susceptibility, but no variants have been robustly associated with
ADHD. We report a genome-wide association meta-analysis of 20,183 individuals
diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide
significance in 12 independent loci, finding important new information about the underlying …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute
substantially to ADHD susceptibility, but no variants have been robustly associated with
ADHD. We report a genome-wide association meta-analysis of 20,183 individuals
diagnosed with ADHD and 35,191 controls that identifies variants surpassing genome-wide
significance in 12 independent loci, finding important new information about the underlying …
[PDF][PDF] Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
… Two of the genome-wide significant loci defined by this process in the ADHD meta-analysis
include … In order to refine the genome-wide significant loci, we defined a credible set of
variants in each locus … We applied the Bayesian credible set analysis to each of the 12
genome-wide significant loci …
include … In order to refine the genome-wide significant loci, we defined a credible set of
variants in each locus … We applied the Bayesian credible set analysis to each of the 12
genome-wide significant loci …
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