… tumor targeting and more effective in elimination of cancer … 肿瘤浸润淋巴细胞”(tumor infiltrated
lymphocytes，TIL)过继疗法… 载体的TCR基因工程技术首次在黑色素瘤抗原特异的TCR研究…

… Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes
confers anti-tumor reactivity[J]. J Immunol, 1999, 163(1): 507-513 [11] Hillerdal V, Nilsson B, …

… into these reporter cells, we can effectively select TCR … selected TCR candidates are then
transferred into primary human T … T cell clonotypes and underestimate antigen-reactive T cell …

… enhances tumor treatment efficacy of adoptively transferred tumor-specific T … Efficient transfer
of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor …

… T cells (TCR-T) targeting immunogenic tumor antigens can effectively kill tumors without …
基本步骤 Figure 1 The basic steps of tumor-specific antigen-reactive T cell immunotherapy …

… 款TCR药物的上市开启了TCR药物开发的新纪元,多项TCR药物… 性蛋白酪氨酸激酶(lymphocyte-specific
protein tyrosine kinase, … transfer of MART-1 T-cell receptor transgenic lymphocytes …

… Finding the antigen-reactive T cell receptors (TCR), T cells … -specific TCRs, we sought to
develop an efficient approach to … cloned TCRs will be used to transduce primary lymphocytes …

… In 2003, VacA was found to efficiently block both il-2 … have peripheral mechanisms to deal
with the self antigen reactive … Besides, the TCR activation is also required for the expression of …

… Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes
confers anti-tumor reactivity[J]. J Immunol, 1999, 163(1): 507-513 [11] Hillerdal V, Nilsson B, …

… , our results suggest that LASIK can be safely and effectively … The T cell receptor (TCR) V8
and V6 genes are preferentially … the accumulation of antigen-reactive T cells at the site of the …