p53 介导缺血性脑损伤的神经元死亡

LZ Hong, XY Zhao, HL Zhang - Neuroscience Bulletin, 2010 - Springer
… Current evidence indicates that p53 encodes a sequence-… of p53 under in vivo conditions
is the specific deletion of p53 gene. … B: Under various cellular stress, p53 is phosphorylated at …

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DDĐ Day - Cell - mhlw-grants.niph.go.jp
… 8 of the p53 gene by genomic PCR and direct sequencing "" … of Ser296 phosphorylation, we
first measured the in vitro kinase … Our present data thus provide strong evidence that 14-3-3y …

Cdk5 与神经退行性变核心的异常细胞周期激活

R Requejo-Aguilar - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… The overwhelming evidence is that abnormal phosphorylation … Further, in vitro and in vivo
models of AD show an increase … by DNA damage in neurons and the expression of p53 target …

乙醇是如何诱导神经细胞凋亡的?

Y Moon, Y Kwon, S Yu - 中国神经再生研究(英文版), 2013 - sjzsyj.com.cn
… of evidence suggests that ethanol can lead to damage of … the ethanol-induced damage of
neuronal cells remains unclear. … the phosphorylation of p53, which led to accumulation of p53

纤维蛋白通过促进重组酶RAD51 在DNA 损伤位点的招募参与同源重组修复

慕艳华, 韩金花, 邬明杰, 李宗芳, 杜轲… - … 版)(B 辑: 生物医学和 …, 2023 - jzusb.zjujournals.com
… In vitro pull-down assays demonstrated a direct binding … These findings provided compelling
evidence for a direct … Upon DNA damage, FBL is recruited to the sites of DNA breaks. FBL …

对活性氧介导的神经变性机制的新见解

S Wakatsuki, T Araki - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Evidence provides new insights into the mechanism of … DNA damage by chemotherapeutic
reagents activates p53 … In our in vitro Wallerian degeneration model, a significant increase in …

Identification of new key genes for type 1 diabetes through construction and analysis of protein–protein interaction networks based on blood and pancreatic islet …

N Safari‐Alighiarloo, M Taghizadeh… - Journal of …, 2017 - Wiley Online Library
… To address this issue, there is evidence that the full … This procedure is considered as a
well-established in vitro model of T1D … Apoptosis and p53 signaling were the apoptotic-enriched …

人脐带间充质干细胞通过IGF1R-CHK2-p53 信号轴减轻2 型糖尿病雄性大鼠糖尿病肾病

张昊, 王新舒, 胡铂, 李沛城, 伊尔番… - … 版)(B 辑: 生物医学和 …, 2024 - jzusb.zjujournals.com
… (p-CHK2) and phosphorylated p53 (p-p53). Compared with the … Our findings provide novel
evidence supporting the use of … B-induced DNA damage in human keratinocytes in vivo. Mol …

共济失调-毛细血管扩张突变在小脑完整性和功能中起重要作用

Y Mitiagin, A Barzilai - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… Accumulating evidence indicates that ATM has numerous … of ATM are the genome guardian
p53 and the histone H2AX. … phosphorylation is one of the earliest signs of DNA damage. …

促进缺血视网膜神经元DNA 修复的糖原合酶激酶3β 抑制剂SB216763

J Zhang, ZP Lai, P Chen, Y Ying, J Zhuang… - 中国神经再生研究(英文 …, 2021 - sjzsyj.com.cn
… activity by suppressing its phosphorylation. Taken together, … Both in vivo and in vitro evidence
have confirmed that GSK-3 … inhibitor SB216763 suppressed DNA damage and promoted …