Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways
A Wisner, E Dufour, M Messaoudi… - Proceedings of the …, 2006 - National Acad Sciences
… receptor-dependent enkephalinergic pathways. Here we demonstrate the functional specificity
in vivo of human Opiorphin. The pain-suppressive potency of Opiorphin is as effective as …
in vivo of human Opiorphin. The pain-suppressive potency of Opiorphin is as effective as …
[PDF][PDF] Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent δ-opioid pathways
H Javelot, M Messaoudi, S Garnier… - Journal of Physiology …, 2010 - researchgate.net
… -mediated antinociception while µ-opioid agonists modulate the antidepressant potency
produced by δ-opioid agonists. In summary, opiorphin, is a systemically active key modulator of …
produced by δ-opioid agonists. In summary, opiorphin, is a systemically active key modulator of …
Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice
… The relatively weak antinociceptive effects of opiorphin could be due to its route of …
enkephalinergic pathways. This could result from a weak metabolic stability and/or bioavailability of …
enkephalinergic pathways. This could result from a weak metabolic stability and/or bioavailability of …
The antidepressant-like effect of human opiorphin via opioid-dependent pathways in mice
QZ Yang, SS Lu, XZ Tian, AM Yang, WW Ge… - Neuroscience letters, 2011 - Elsevier
… human opiorphin has antidepressant-like effect. The antidepressant-like effect of opiorphin
… the antidepressive effect of opiorphin is through opioid-dependent pathways. Endogenous …
… the antidepressive effect of opiorphin is through opioid-dependent pathways. Endogenous …
Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice
X Tian, J Chen, W Xiong, T He, Q Chen - Peptides, 2009 - Elsevier
… and human opiorphin are the only three natural enkephalin … by activating endogenous
opioid-dependent pathways. Opioid … of opiorphin on colonic contractions and antinociception are …
opioid-dependent pathways. Opioid … of opiorphin on colonic contractions and antinociception are …
[PDF][PDF] Systemically active human opiorphin is a potent yet non-addictive analgesic without drug tolerance effects
C Rougeot, F Robert, L Menz, JF Bisson… - Journal of physiology …, 2010 - academia.edu
… duration of the antinociceptive action of opiorphin with reference … pathway contributes to the
antinociceptive effects induced by … This suggests that the natural dual inhibitor opiorphin may …
antinociceptive effects induced by … This suggests that the natural dual inhibitor opiorphin may …
STR-324, a stable analog of opiorphin, causes analgesia in postoperative pain by activating endogenous opioid receptor–dependent pathways
P Sitbon, A Van Elstraete, L Hamdi, V Juarez-Perez… - …, 2016 - pubs.asahq.org
… Opiorphin is a naturally occurring potent analgesic human peptide. It protects enkephalins
… effects mediated via opioid-dependent antinociceptive pathways. Opiorphin analog should …
… effects mediated via opioid-dependent antinociceptive pathways. Opiorphin analog should …
[HTML][HTML] HUMAN OPIORPHIN IS A NATURALLY OCCURRING ANTIDEPRESSANT ACTING SELECTIVELY ON ENKEPHALIN-DEPENDENT-OPIOID PATHWAYS 1 …
H JAVELOT, M MESSAOUDI, S GARNIER… - jpp.krakow.pl
… In summary, opiorphin, is a systemically active key modulator of both pain perception and …
Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc …
Human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc …
[PDF][PDF] The Discovery of Rat Sialorphin and Human Opiorphin: new modulators of opioid-dependent pathways
C Rougeot, M Messaoudi - researchgate.net
… control of neurotransmission pathways of pain and in the modulation of cerebral structure …
Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc …
Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways. Proc …
Human Opiorphin an Endogenous Inhibitor of Enkephalin-Inactivating Ectopeptidases that Displays Antinociception: A Review
M Wollemann, C Rougeot - Current Bioactive Compounds, 2016 - ingentaconnect.com
… , that human opiorphin is “a natural antinociceptive modulator of opioid-dependent pathways”.
… The antidepressant-like effect of human opiorphin via opioid dependent pathways in mice. …
… The antidepressant-like effect of human opiorphin via opioid dependent pathways in mice. …