人干细胞来源的小胶质细胞将成为阿尔茨海默病研究必不可少的工具箱

T Liu - 中国神经再生研究(英文版), 2021 - sjzsyj.com.cn
genes are identified as risk factors for AD, frontotemporal dementia and other neurodegenerative
diseases. … So, we can integrate tet-on inducible progerin into the genome of hMGL to …

患者特异性单核细胞衍生的小胶质细胞作为神经退行性疾病的筛查工具

H Quek, AR White - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… microglia to study the recruitment of myeloid cells. It is further … , mainly through a genome
integrating delivery method (ie … characteristics such as disease severity, genetic aberrations, …

引起Krabbe 疾病的半乳糖脑苷脂酶突变的杂合载体具有损伤的小胶质细胞功能和髓鞘损伤的有缺陷的修复

NJ Scott-Hewitt, CJ Folts, MD Noble - 中国神经再生研究(英文版), 2018 - sjzsyj.com.cn
genetic risk factors may contribute to complex diseases by … of the strongest vulnerability loci
identified in the genome-wide … of Triggering receptor expressed on myeloid cells-2 (Trem2), …

阿尔茨海默病建模: 对更好的可转化和可复制小鼠模型的考虑

JD Cho, M Yang, I Santa-Maria - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
… the transgene can integrate into the genome at a random … Additionally, one of the strongest
genetic risk factor alleles for … In addition, genome-wide studies are being done to identify

将蛋白质组学发现转化为治疗痴呆症药物的策略

A Halder, E Drummond - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… were also found to have a high risk of bias, as studies showing … enhance our ability to integrate
genomics, proteomics, and 3D… ’s TREAT-AD genetics score, which combines studies from …

新冠肺炎后的阿尔茨海默病风险: 从神经退行性传染假说角度看

E Olivera, A Sáez, L Carniglia, C Caruso… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… CR1 are among AD risk factors identified by genome-wide association … between infectious
processes and AD risk genes. … (2021b) showed that pericytes, when integrated into a cortical …

[PDF][PDF] 阿尔茨海默病的平衡转移: 小胶质细胞在神经炎症, 神经元存活和神经发生中的复杂作用

SC Gray, KJ Kinghorn, NS Woodling - 中国神经再生研究(英文版), 2020 - sjzsyj.com.cn
… that whilst the heterogeneity of myeloid cells in the brains of … , genetic risk factors associated
with neurological disorders … experimental approaches that integrate data from multiple …

二甲双胍有望用于治疗神经系统疾病: 生物标志物指导的治疗

A Loan, C Syal, M Lui, L He, J Wang - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… various risk factors such as aging, lifestyle, genetics, and environment, it is important to identify
… within the mitochondrial genome from AD patient brain tissues. This work has suggested …

调节线粒体生物能学可作为阿尔茨海默病的治疗策略

IG Onyango - 中国神经再生研究(英文版), 2018 - sjzsyj.com.cn
… Additional risk genes that have been identified by genome-wide association … risk loci
associated with sAD are: sortilin-like receptor 1 (SORL1), triggering receptor expressed on myeloid

阿尔茨海默病和伴随疾病的线粒体生物能/慢性炎症相关病理

MA Filippov, OG Tatarnikova… - 中国神经再生研究 …, 2021 - sjzsyj.com.cn
… The risk factors for NCDs development are age, genetic … on genetics and environmental
factors and defines the … effects of recombinant genetic construct integration in genomic DNA. …