… mutations in the KISS1R and KISS1 genes and loss-of-function mutations in the MKRN3,
LIN28, and DLK1 genes … of gene networks involving multiple variant genes on pubertal initiation…

… 1.1 KiSS-1/GPR54 基因的克隆和结构 KiSS-1 基因是研究人恶性黑色素… puberty due to
luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation …

… precocious puberty in recent 10 years and prevent and avoid the occurrence of precocious
puberty. … puberty from 2007 to 2016, it provides a reference for the researchers of precocious …

… of rapamycin expression during onset of puberty in female rats [J]. … KiSS1 gene as a novel
mediator of TGFbeta-mediated cell … of VEGFA isoforms in p53 mutant breast cancer: can it be …

在哺乳动物中, 性激素水平呈昼夜节律性, 且这种节律性由机体的生物钟⁃ 下丘脑视交叉上核控制
, 而生物钟的紊乱会导致机体内环境发生改变, 性激素的昼夜节律亦被破坏, 从而可能引发一些…

… Gene mutations were detected in only 14 of 20 patients, … 相关的基因有 kisspeptin 1 蛋白
(kisspeptin 1,KISS1)及其受体基 因等[14-… Genetic evaluation of patients with delayed puberty and …

… than many other single-gene disorders due to the high … mutations due to recombination
between functional gene and … inhibits Kiss1 and GnRH expression, leading to puberty delay[J]. …

… Garc侏a-Ortega 等[7]报道了TAC3 基 因编码的蛋白质NKB 和KISS1 基因编码的蛋白 Kisspeptin
在直接作用于人卵巢卵泡颗粒细胞,促进卵 泡成熟.蒋书东等[9]报道,母犬下丘脑,垂体和卵巢中 …

… This paper reports the clinical diagnosis and treatment, as well as genetic defects, of a child
… , intractable epilepsy, and central precocious puberty. High-resolution karyotype analysis is …

… With the development of gene sequencing technology, more and more studies have found
… by somatic mutations of genes. In this paper, somatic mutation⁃related pathogenic genes of …