… , such as interleukin-1β and interleukin-18. These … NLRP3 mediated inflammasome activation
is a pivotal signaling pathway in the innate immune system of the central nervous system …

… Along with other immune cells, macrophages facilitate insulin … mediates the recognition and
engulfment of apoptotic cells.… -1, and NLRP3, is the most fully characterized inflammasome. …

… immunity and inflammasomes: The innate immune system is … -inflammatory cytokines, such
as interleukin (IL)-1β and IL-18. … that the NLRP3 inflammasome-mediated neuroinflammation …

… adaptive responses mediated by the central nervous system, … members in mice and the
NLRP3 inflammasome is one of the … This is enough to produce an ATPmediated Ca2+ signal in …

… NO is synthesized, mediating the inflammatory response. Several … in the immune function of
the innate immune system. The … only activates the interleukin-1β (IL-1β) and interleukin-18 (IL…

… the cleavage of inactive interleukin (IL)-1β into its active form.… It has been shown that the
NLRP3 inflammasome mediates … Consequently, the production of inflammatory cytokines in …

… Cells of the innate immune system use pattern recognition … ry responses mediating glial
activation, cytokine production and neu… result in release of mature interleukin-1β. Furthermore, …

… production and secretion of interleukin-1β through pyrin domain-containing protein 3
inflammasome-independent processing of procaspase-3 in … Moreover, either siRNA-mediated …

… /or inhibit inflammasome activation in innate immune cells by … signal transduction by producing
Toll/interleukin-1 receptor (… 虽然会诱导NLRP3炎症小体表达且不影响胞内Pro-IL-1β水平，…

… colonic mucosa, represents an immune-mediated disorder and is a … In our study, DSS caused
an increase in immune cell … sion of DSS-induced NLRP3 inflammasome activation. Overall, …