… decreased during acute renal ischemic injury and acute cellular rejection… NLRX1 function
extends to the control of mitochondrial activity and prevention of oxidative stress and apoptosis …

… OA, we hypothesized that NLRX1 may participate in OA through regulating NF-κB signaling.
… apoptosis, associated with preventing oxidative stress and sustaining mitochondrial activity […

… The dependence of NLRX1 function on SARM1’s expression places NLRX1 as a protein …
to explain the function of NLRX1 and SARM1 in physiological and apoptotic conditions. Recent …

… NLRX1 actually shuttles from the cytosol to the mitochondria … oxidative stress is also a key
driver of cell death through JNK … NLRX1 reportedly exerts protective effects against apoptosis …

… injury and apoptosis by decreasing oxidative stress in a mouse … to the sites of infection or
tissue injury. Within the peripheral … NLRX1 dampens oxidative stress and apoptosis in tissue …

… homeostasis and metabolic balance, as well as apoptosis and … The interaction between
oxidative stress and autophagy has … of NLRX1 in the regulation of mitochondrial function, and …

… and acts to dampen inflammatory responses, unlike the … and trafficking of NLRX1 to the
mitochondria is unknown. Further … NLRX1 was deemed essential for TNF-α-mediated apoptosis. …

… impact of NLRX1/UQCRC2 on mitochondrial function has not … and CNS, NLRX1 may dampen
inflammatory responses by … intrinsic apoptosis regulation occurs via NLRX1 interactions …

… in mitochondria 8,9 . Recent research has shown that NLRX1 has roles in modulation of
mitochondrial function, … NLRX1 deficiency dampens the inflammation and mortality induced by …

… and PARP-1, we suggest an indirect action regulated by NLRX1 in the mitochondria to …
NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity…