[HTML][HTML] 利用生物信息学分析人ZUP1基因在乳腺癌中的表达及机制

张光君, 涂刚 - 第二军医大学学报, 2020 - html.rhhz.net
… ) in breast cancer. Methods Gene information and clinicopathological data of breast cancer
… Bioinformatics methods were used for prediction of miRNAs and ubiquitin ligase that could …

[PDF][PDF] 雌, 孕激素受体的转录激活与调控

辛启亮, 邱静涛, 崔胜, 夏国良, 王海滨 - 2016 - ir.ioz.ac.cn
… that the term p160 encompasses a novel family of structurally-… form a dimeric RING finger
E3 ubiquitin ligase. Several lines … appears to contribute to breast cancer development in Brca1-…

[PDF][PDF] 基于TRIM 家族讨论泛素连接酶TRIM46 研究进展

盛瀚萱, 张连峰, 张丽 - 中国比较医学杂志, 2022 - zgbjyx.cnjournals.com
… Mmu-miR-1894-3p inhibits cell proliferation and migration of breast cancer cells by … TRIM9,
a novel brainspecific E3 ubiquitin ligase, is repressed in the brain of Parkinson’ s disease …

黑色素瘤抗原泛素连接酶的研究进展

严峻, 文静, 李希圣, 莫立根 - 肿瘤防治研究, 2018 - zlfzyj.com
… target for cancer markers and … with E3-RING ubiquitin ligase to form MAGE-RING ligase
complex(MRLs). MRLs are regulatory factors for ubiquitination to regulate the activity of the ligase

利用CRISPR/Cas9 技术构建环指蛋白126 基因敲除小鼠

高梦樵, 艾东旭, 李钰, 孙菲, 王进, 范君文, 袁征… - 实验动物与比较 …, 2019 - slarc.org.cn
E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor
p21 for ubiquitinmediated degradation [J]. Cancer Res, 2013, 73:385-394. [12] Zheng M…

[PDF][PDF] 人DC-SIGN 全长编码区基因的克隆及其胞外段的原核表达

刘莹, 左大明, 卢晓, 张丽芸, 陈政良 - 细胞与分子免疫学杂志, 2009 - researchgate.net
… by repressingBmi21 expression and down2regulating Akt activity in breast cancer cells[ J ].
… R ING finger ubiquitin ligase ca2 pable of synergistically enhancing Mdm2 ubiquitination [ J ]. …

[PDF][PDF] 泛素连接酶E3 与泛素链修饰类型特异性研究进展

陈杨, 王富强, 徐平 - 生命科学, 2017 - lifescience.sinh.ac.cn
… the most recent advances in E3 ubiquitin ligases study, and … A pathogen type III effector
with a novel E3 ubiquitin ligase … FOXM1 ubiquitination and degradation in breast cancer

[HTML][HTML] 基于PROTACs 策略的抗肿瘤药物研究进展

段迎超, 翟晓雨, 秦文平, 关圆圆 - 药学学报, 2017 - html.rhhz.net
ubiquitin-proteasome system. Recently, the development of specific small-molecule ligands
for several E3 ligases (… and considered a novel approach for therapy of cancers. There are …

泛素介导的蛋白质降解与肿瘤发生

李艳凤, 张强, 朱大海 - 遗传, 2006 - chinagene.cn
… The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived
mutation. J Biol … Proteasome inhibitors: a novel class of potent and effective antitumor …

[PDF][PDF] 组蛋白泛素化与去泛素化对染色质和基因表达的研究进展

林烨, 裴培, 王珊 - Progress in Modern Biomedicine, 2019 - biomed.cnjournals.com
… interacts with the p53-inhibiting ubiquitin ligase MDM2 [J]. … : a novel epigenetic regulator of
stem cell identity and cancer[… ubiquitin ligases[J]. J Biol Chem, 2013, 288(23): 16579-16587 …