[PDF][PDF] 人类早衰症的发病机制及干预方法

王泽华, 李洪宇, 曲静, 张维绮, 刘光慧 - 2018 - ir.ioz.ac.cn
Phenotype and course of Hutchinson-Gilford progeriaHutchinson-Gilford progeria syndrome
cellular phenotypes. … A high throughput phenotypic screening reveals compounds that …

下颌骨发育不良伴A 型脂肪代谢障碍一家系报告

向上, 张璇, 李雪怡, 毕杨, 肖农 - 临床儿科杂志, 2014 - jcp.xinhuamed.com.cn
Phenotype and course of HutchinsonGilford progeria … in children with Hutchinson-Gilford
progeria syndrome [J]. Proc Natl … Neurologic features of Hutchinson-Gilford progeria syndrome

单中心11 例青春期及成人早老症临床与基因特征分析.

陈欣悦, 余洁, 崔云英, 阳洪波, 刘赫… - Chinese Journal of …, 2024 - search.ebscohost.com
… in a mouse model of HutchinsonGilford progeria syndrome[J]. … a restoration rescue
hutchinsongilford progeria syndrome [J]. … HutchinsonGilford Progeria syndrome‑current status …

人干细胞来源的小胶质细胞将成为阿尔茨海默病研究必不可少的工具箱

T Liu - 中国神经再生研究(英文版), 2021 - sjzsyj.com.cn
… However, it is worthy to note that different protocols maybe produce different phenotypes of
… system, and investigating mechanisms underlying the entire life course (Figure 1). Thus, we …

CRISPR/Cas9 及其衍生编辑器在衰老研究中的应用进展

龚仕涛, 王宇, 陈宇庭 - 合成生物学, 2022 - synbioj.cip.com.cn
… and a pro-inflammatory phenotype called senescence-associated secretory phenotype
and aging related diseases including progeria syndrome, cardiovascular disease, agerelated …

长链非编码RNA 在衰老过程中的分子标志及其对衰老相关疾病的显著影响

SAM Sherazi, A Abbasi, MU Abdullah Jamil… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… out long non-coding RNAs, a new class of powerful gene regulatory elements. However,
their … Specific changes in the reservoirs of expressed proteins control the phenotypic changes …

基因编辑技术及其在糖生物学研究中的应用.

章恩华, 邱宏 - Chinese Journal of Biochemistry & Molecular …, 2024 - search.ebscohost.com
… In vivo base editing rescues HutchinsonGilford progeria syndrome in mice [J]. Nature, 2021,
589(7843): … A phenotype survey of 36 mutant mouse strains with gene⁃targeted defects in …

CRISPR/Cas 系统的分类及研究现状

高维崧, 窦金萍, 韦双, 刘兴健, 张志芳, 李轶女 - 生物技术进展, 2022 - swjsjz.cn
: CRISPR 技术作为一种新型的基因编辑技术, 被广泛应用于微生物, 动物和植物领域. 对
CRISPR/Cas 系统的起源, 分类特点等进行了阐述, 重点梳理了CRISPR/Cas 系统分类的发展历程, 并…