… without it, the programmed cell death necessary during cavitation … loss of adult cerebellar
and retinal neurons, and in … dramatic deficits in cerebellar Purkinje and granule cell precursors (…

… that can culminate in cell death. In proliferating … of Purkinje neurons, which are specifically
cerebellar cells. The firing rate of Purkinje neurons is among the highest in the neuronal cells …

… treatment that delays or attenuates cerebellar degeneration and/or … Thus persistent ER stress
eventually leads to cell death. … , leading to degeneration of Purkinje neurons (panel ii). (C) …

… population of cerebellar granule cells and neurons die, … the cell cycle to the programmed
cell death mechanisms[59]. Interestingly, the brain regions with a high vulnerability to neuronal …

… Programmed cell death is mediated by gene expression events and it is a critical … regulation
of neuronal death of postmitotic cerebellar granule cells and Purkinje neurons. GABAergic …

… cell death in a 6-OHDA model of PD, a stem cell has no cues to respond for migration and
eventually cell … by progressive death of Purkinje neurons in the cerebellum. Clinically, these …

… of ethanol exposed neurons, increased cellular death happened only after specific triggers.
… damage in cerebellar granule neurons cultures from the beginning of cell death assessment. …

… to neuronal mitochondria, leading to programmed cell death, … among the Purkinje cell
bodies in the cerebellum, degenerat… (red arrows) and degeneration of Purkinje neurons without …

… However, studies in LYSTdeficient mice have shown cerebellar Purkinje cell loss and …
Purkinje cells in cerebellar functioning and their complexity as the brain’s most intricate neurons…

… This pathway is well defined in the cerebellar Purkinje cell, in part because disruption of …
In Purkinje cells an excitatory glutamate signal from the cerebellar parallel fibers is transduced …