Background Alterations in gene expression in the suicide brain have been reported and for
several genes DNA methylation as an epigenetic regulator is thought to play a role. rRNA
genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery
and levels of rRNA gene promoter methylation determine rRNA transcription.
Methodology/Principal Findings We test here by sodium bisulfite mapping of the rRNA
promoter and quantitative real-time PCR of rRNA expression the hypothesis that epigenetic …

Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain |
CiNii Research … Promoter-wide hypermethylation of the ribosomal RNA gene promoter in
the suicide brain …