Reactivity of inducer cell subsets and T8-cell activation during the human autologous mixed lymphocyte reaction
PL Romain, C Morimoto, JF Daley, LS Palley… - Clinical Immunology and …, 1984 - Elsevier
To characterize the responding T cells in the autologous mixed lymphocyte reaction (AMLR),
T cells were fractionated into purified subpopulations employing monoclonal antibodies and
a variety of separation techniques including fluorescence-activated cell sorting. It was found
that isolated T4 cells, but not T8 cells, proliferated in response to autologous non-T cells.
More importantly, within the T4 subset, the autoreactive population was greatly enriched in a
fraction reactive with an autoantibody from patients with juvenile chronic arthritis (JRA) or the …
T cells were fractionated into purified subpopulations employing monoclonal antibodies and
a variety of separation techniques including fluorescence-activated cell sorting. It was found
that isolated T4 cells, but not T8 cells, proliferated in response to autologous non-T cells.
More importantly, within the T4 subset, the autoreactive population was greatly enriched in a
fraction reactive with an autoantibody from patients with juvenile chronic arthritis (JRA) or the …
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