Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant …
D Martin, AI Rojo, M Salinas, R Diaz, G Gallardo… - Journal of Biological …, 2004 - ASBMB
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal against
multiple apoptotic insults. In addition, phase II enzymes such as heme oxygenase-1 (HO-1)
protect cells against diverse toxins and oxidative stress. In this work, we describe a link
between these defense systems at the level of transcriptional regulation of the antioxidant
enzyme HO-1. The herb-derived phenol carnosol induced HO-1 expression at both mRNA
and protein levels. Luciferase reporter assays indicated that carnosol targeted the mouse …
multiple apoptotic insults. In addition, phase II enzymes such as heme oxygenase-1 (HO-1)
protect cells against diverse toxins and oxidative stress. In this work, we describe a link
between these defense systems at the level of transcriptional regulation of the antioxidant
enzyme HO-1. The herb-derived phenol carnosol induced HO-1 expression at both mRNA
and protein levels. Luciferase reporter assays indicated that carnosol targeted the mouse …
以上显示的是最相近的搜索结果。 查看全部搜索结果