[PDF][PDF] 癌症中p53 失活的分子机制和靶向p53 的抗癌药物研究进展
周建林 - 生命科学研究 - smkx.hunnu.edu.cn
… The mutation pattern of p53 protein in human cancer tissues determined using cBioPortal
TAD: Transactivation domain; DBD: DNA binding domain; Tetramer: Tetramerization domain. …
TAD: Transactivation domain; DBD: DNA binding domain; Tetramer: Tetramerization domain. …
散发嗜铬细胞瘤中VHL 基因及蛋白表达的研究
赵志强 - 2010 - ir.lzu.edu.cn
… mutation,and then,approach the clinical significance. … man-made VHL gene probe investigated
the expression of VHL … protective effect on the human leukocyte antigen. Results (1) The …
the expression of VHL … protective effect on the human leukocyte antigen. Results (1) The …
[PDF][PDF] 一VHL 家系致病基因突变的检测与分析
张前军， 李汶， 李双飞， 汤蔚琳， 李麓芸… - 现代生物医学 …, 2012 - biomed.cnjournals.com
… , China; 2 Reproductive and Genetic Hospital of Citic-Xiangya, … of VHL gene mutations
and discuss the pathogenic, clinical characteristics, diagnosis and treatment progress of VHL …
and discuss the pathogenic, clinical characteristics, diagnosis and treatment progress of VHL …
[PDF][PDF] 低氧诱导因子在肾透明细胞癌中作用的研究进展
项鹏程， 孙鹏程， 刘玉伟， 卢云汉… - 现代生物医学 …, 2017 - biomed.cnjournals.com
… VHL gene has the function of regulating transcription, stabling cell growth related gene
and regulating the cell cycle, the mutations, deletions… Human cancers converge at the HIF-2alpha …
and regulating the cell cycle, the mutations, deletions… Human cancers converge at the HIF-2alpha …
[HTML][HTML] 姜黄素衍生物EF24 的抗肿瘤机制研究进展
刘海涛， 王逻逻， 刘连新 - 世界华人消化杂志, 2012 - wjgnet.com
… 1需要VHL蛋白的功能. 近期的研究表明VHL可以连接并稳定微管[47], 这个发现可以解释EF24发挥
抗HIF-1活性的作用为什么需要有功能的VHL, 很可能是因为EF24稳定细胞内微管是依赖VHL…
抗HIF-1活性的作用为什么需要有功能的VHL, 很可能是因为EF24稳定细胞内微管是依赖VHL…
VHL综合征家系合并VHL基因和TP53基因突变的临床表型及基因突变分析研究
唐俊， 彭宏伟， 代喆， 郑航， 孟哲 - 临床泌尿外科杂志, 2023 - lcmw.whuhzzs.com
… Val31Ile) which were deemed pathogenic and uncertain significance, respectively.Conclusion
We identified a rare co-variation of VHL and TP53 in a family with VHL disease, …
We identified a rare co-variation of VHL and TP53 in a family with VHL disease, …
[PDF][PDF] 骨髓基质细胞中Von Hippel-Lindau 基因的siRNA 表达载体构建及其检测
邹多宏， 赵君， 夏伦果， 张秀丽， 蒋欣泉， 黄远亮 - 上海口腔医学, 2010 - sjos.cn
… were used to detect the gene silencing effect. In order to improve transfection efficiency of
siRNA$VHL as well as the effect of the VHL gene silencing, pLenti$ mi$VHL was constructed. …
siRNA$VHL as well as the effect of the VHL gene silencing, pLenti$ mi$VHL was constructed. …
[HTML][HTML] 过度活化Notch1 信号促进肾癌细胞增殖的机制研究
许乐， 林宗明， 朱煜， 王国民 - 肿瘤防治研究, 2014 - zlfzyj.com
… VHL综合征可表现为家族性肾透明细胞癌.通过对VHL综合征患者进行分子遗传学研究,发现了
VHL抑癌基因.目前研究已证实VHL基因异常在家族性和散发性肾透明细胞癌的发病中都起着关键…
VHL抑癌基因.目前研究已证实VHL基因异常在家族性和散发性肾透明细胞癌的发病中都起着关键…
[PDF][PDF] 肾细胞癌基因组学研究推动靶向治疗发展
张蒙， 杨泽雨， 谢良富， 蔡志明， 吴松 - 生命科学, 2014 - lifescience.sinh.ac.cn
… ,VHL 综合征基因(von Hippel-Lindau gene, VHL) 和受体 酪氨酸激酶基因(MET or MNNG HOS
transforming gene, c-… Causes and consequences of DNA hypomethylation in human cancer. …
transforming gene, c-… Causes and consequences of DNA hypomethylation in human cancer. …
[PDF][PDF] 丐一19980722078
M Reiss - 1998 - researchgate.net
… The current study demonstrates that two different mutations within the C-terminus of the
TBR-II receptor that we had identified in human cancer cells abolish the signaling function of the …
TBR-II receptor that we had identified in human cancer cells abolish the signaling function of the …