福尔马林所致炎性痛后脑内三种COX 亚型的变化及不同选择性COX 抑制剂的镇痛效应比较
路志红， 熊晓云， 孟静茹， 刘振国… - 中国临床药理学与 …, 2005 - manu41.magtech.com.cn
… COX-1 is constitutively expressed in most tissues . The higher levels … In contrast, COX-2
expression is markedly inducible in … New classes of selective COX-2 inhibiting medications have …
expression is markedly inducible in … New classes of selective COX-2 inhibiting medications have …
姜黄素和芹菜素: 对抗阿尔茨海默病慢性神经炎症有希望
M Venigalla, E Gyengesi, G Münch - 中国神经再生研究(英文版), 2015 - sjzsyj.com.cn
… Curcumin inhibits IL-6 mediated signalling via inhibition of IL-6 … (diferuloylmethane) inhibits
constitutive and IL-6-inducible STAT3 … antioxidants attenuate the expression of inducible nitric …
constitutive and IL-6-inducible STAT3 … antioxidants attenuate the expression of inducible nitric …
[HTML][HTML] COX-2 与胃癌关系的研究进展
王俊先， 张开光 - 世界华人消化杂志, 2009 - wjgnet.com
… COX-2 is an inducible enzyme which is over expressed in … COX selective inhibitors
can be used as one of the basic anti-… COX-1又称结构性环氧合酶(constitutive COX), 由599-600个…
can be used as one of the basic anti-… COX-1又称结构性环氧合酶(constitutive COX), 由599-600个…
[HTML][HTML] 前列腺素类物质在胃肠道肿瘤发病机制中的作用
丁岩冰， 肖炜明， 王学浩 - 世界华人消化杂志, 2006 - wjgnet.com
… , normally, COX-1 is constitutively expressed in a broad range of … from most cells but highly
inducible in response to inflammatory … use of non-steroidal anti-inflammatory drugs alone or in …
inducible in response to inflammatory … use of non-steroidal anti-inflammatory drugs alone or in …
前列腺素受体配体, 脂肪酸衍生物和相关酶抑制剂对神经轴突细胞的损伤/保护
NA Sharif - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… Therefore, in some ways, these enzyme inhibitors lack the degree of specificity to address
the selectivity offered by receptor-selective antagonist drugs. Nevertheless, as described …
the selectivity offered by receptor-selective antagonist drugs. Nevertheless, as described …
COX-2 在MCD 饮食诱导的脂肪性肝纤维化中的作用及与PPARα 的关系
王世研， 高向东， 李宝琴， 贾彦红 - 河北大学学报(自然科学版), 2008 - xbzrb.hbu.edu.cn
… Activation of PPARa down—regulates the expression of COX一2 while treatment of
selective COX-2 inhibitor ameliorates fibrosising steatohepatitis via activating PPARa. …
selective COX-2 inhibitor ameliorates fibrosising steatohepatitis via activating PPARa. …
靶向一氧化氮/cGMP 信号通路治疗慢性疼痛
DY Li, SJ Gao, J Sun, LQ Zhang, JY Wu… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… inducible NOS (iNOS) (Fang et al., 2022; Sun et al., 2022). nNOS and eNOS are constitutively
… this effect could be antagonized by selective nNOS inhibitor and PI3Kγ/AKT antagonists. …
… this effect could be antagonized by selective nNOS inhibitor and PI3Kγ/AKT antagonists. …
一氧化氮在神经退行性疾病中的作用: 非类固醇性抗炎药的治疗前景
GH Doherty - Neuroscience Bulletin, 2011 - Springer
… Neuroinflammation has been found in some neurodegenerative conditions, and inhibition of
… Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral …
… Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral …
[HTML][HTML] pGL3-Basic-COX-2-promoter 报告基因重组质粒的构建及其功能鉴定
李琦， 周利红， 王炎， 孙珏， 高虹， 范忠泽 - 世界华人消化杂志, 2008 - wjgnet.com
… COX-1为结构型(constitutive)基因, 在正常组织和细胞内表达, 参与维持其正常的生理功能;
COX-2为诱导型(inducible)基因, 静息时不表达, 当细胞受到各种诱导因子刺激时表达上调, 迅速合成, …
COX-2为诱导型(inducible)基因, 静息时不表达, 当细胞受到各种诱导因子刺激时表达上调, 迅速合成, …
[HTML][HTML] 胃黏膜保护的基础与临床研究进展
任建林， 卢雅丕， 潘金水 - 世界华人消化杂志, 2005 - wjgnet.com
… 1975年美国密歇根Upjohn药厂Andre Robert发现前列腺素(prostaglandins, PGs)可明显
防止或减轻皮质类固醇,非甾体类抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs),酸化…
防止或减轻皮质类固醇,非甾体类抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs),酸化…