[HTML][HTML] 过表达组蛋白甲基转移酶ASH1L 对牛卵丘细胞增殖和凋亡的影响

王婉洁, 陈南珠, 邹惠影, 周心仪, 郝海生, 庞云渭… - 畜牧兽医学报, 2023 - html.rhhz.net
… Levels of ASH1L mRNA, protein and H3K36me1/2 methylation … 在牛CCs中,下调ASH1 L表达
可降低H3K36 me1/2/3水平,抑制… ,研究ASH1L过表达对牛CCs中H3K36甲基化状态,细胞增殖和…

[PDF][PDF] 牦牛KDM1B基因CDS区克隆及其在不同组织和卵母细胞成熟过程中的表达

秦文昌, 殷实, 熊显荣, 王斌, 黄向月… - 农业生物技术 …, 2019 - journal05.magtech.org.cn
… -specific histone demethylase 1B, KDM1B)是卵母细 胞中一些印记基因从头甲基化(de novo
methylation)… Research on the structure and function of histone demethylation LSD2 [D]. Thesis …

靶向蛋白非催化功能的药物开发新策略

杨欣语, 宋宜辉, 余斌 - 药学进展, 2022 - pps.cpu.edu.cn
… the conserved catalytic function of proteins face such challenges as poor specificity and …
Structural basis of the recognition of a methylated histone tail by JMJD2A[J]. Proc Natl Acad …

[HTML][HTML] 甲基转移酶SET 结构域家族及其在心血管发育和疾病中的作用

X Jingci, JIE Wei - Journal of Zhejiang University (Medical Sciences …, 2022 - ncbi.nlm.nih.gov
… H3K4, H3K9, H3K36 and H4K20. Additionally, the SETD family catalyzes the methylation of
non-… This article summarizes the basic structures, expression regulation mechanisms and the …

组蛋白去甲基化酶在发育和再生医学的研究.

陈素珠, 李汉梁, 王冰梅 - Progress in Modern Biomedicine, 2016 - search.ebscohost.com
… Histone methylation is one of the important mechanisms of … 基化与基因沉默相关, H3K4 与
H3K36 的甲基化与基因的激活相关[… Enzymatic and structural insights for substrate specificity of a …

[HTML][HTML] 敲低组蛋白甲基转移酶ASH1L基因对牛卵丘细胞表达谱的影响

田雅晴, 崔立欣, 郝海生, 邹惠影, 庞云渭, 赵学明… - 畜牧兽医学报, 2022 - html.rhhz.net
… involved in developmental induction, H3K4 specific histone methyltransferase activity, histone
… 在哺乳动物中,类ASH1L(ASH1-like)可催化组蛋白H3K4和H3K36的甲基化,从而调控同源异形…

剂量补偿和MSL 复合物研究进展

孙敏秋, 林鹏, 陈芸, 王艺磊, 张子平 - 遗传, 2012 - chinagene.cn
… 另外, SET2 (组蛋白H3 的赖氨酸36(H3K36)转甲基酶)的存在, 能形成更多 的H3K36me3, 促进
MSL… Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on …

组蛋白去甲基化酶JMJD1A 及其生物学功能研究进展

湛敏, 周宏灏 - 中国临床药理学与治疗学, 2013 - manu41.magtech.com.cn
… Here,we review the structure,catalytic mechanism, substrate specificity, biological function
and inhibitor of JMJD1A. KEY WORDS JMJD1A;Histone demethylase; Gene transcriptional …

精子染色质完整性对功能的影响及其检测方法研究进展

刘岱缘, 张朝晖, 康现江 - 遗传, 2024 - chinagene.cn
Structural and functional conservation of the NuA4 histone acetyltransferase complex from
… Genome-wide locus-specific DNA methylation repatterning may facilitate rapid evolution of …

组蛋白去甲基化酶LSD1 及其生物学功能

邵根宝, 黄晓佳, 龚爱华, 张志坚, 陆荣柱, 桑建荣 - 遗传, 2010 - chinagene.cn
… (LSD1) indicates that even histone methylation is reversible. … is able to catalyze the specific
removal of methyl groups from … ), 其家族成员可对 H3K9,H3K27,H3K36 等多个位点进行去甲基…