Purpose Several recent studies have used a three‐tissue constrained spherical
deconvolution pipeline to obtain quantitative metrics of brain tissue microstructure from
diffusion‐weighted MRI data. The three tissue compartments, consisting of white matter, gray
matter, and CSF‐like (free water) signals, are potentially useful in the evaluation of brain
microstructure in a range of pathologies. However, the reliability and long‐term stability of
these metrics have not yet been evaluated. Methods This study examined estimates of …

Purpose Several recent studies have utilized a 3-tissue constrained spherical deconvolution
pipeline to obtain quantitative metrics of brain tissue microstructure from diffusion-weighted
MRI data. The three tissue compartments, comprising white matter-, grey matter-, and CSF-
like (free water) signals, are potentially useful in the evaluation of brain microstructure in a
range of pathologies. However, the reliability and long-term stability of these metrics has not
yet been evaluated. Methods This study examined estimates of whole brain microstructure …