… -fat diet and physical inactivity, and the presence of metabolic syndrome or its components,
including central abdominal obesity, hypertension, dyslipidemia and type 2 diabetes (T2D).8 …

… that promotes low-grade inflammation and metabolic dysfunction in … amount and duration of
ROS and RNS generation.8 In many … showed that the effects of calorie restriction are strongly …

… was assessed by structured questionnaires and then categorized into three groups (≤6,
6–8, and >8 h). The prevalence of prediabetes was defined using fasting plasma glucose (100–…

… The study included 33 patients (25 females and 8 males; mean age 46 years) with body
mass index (BMI) values of >40 kg/m 2 . Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, …

… caloric restriction and physical activity. SIRT1 plays a pivotal role in regulating senescence
and has an antiaging effect … PARP-1 cleavage and levels of TNFRI, DR6, caspase-8, Fas, and …

… 6–8 weeks, weighing 200 ± 20 g, specific pathogen free grade) were … Chronic caloric
restriction reduces tissue damage and … and the impairment of long-term potentiation induced by …

… A low-grade inflammation in metabolic syndrome is … oxidative stress,8, 16 it is possible that
the lower GM3 levels in the … .20, 51, 55 Over the long term, TNF-α promotes the transcription …

… are still needed in order to achieve long-term results[8]. In an attempt to find … levels of
evidence described by the Cochrane GRADE system[11]. Using the GRADE scale, the quality level …

… lineage kinase domainlike protein under caspase-8 deficient conditions. Necroptosis can be
… Calorie restriction (CR), ie the limitation of ingested calories without malnutrition, is known …