对利鲁唑作用机制的再思考: 蛋白激酶CK1δ 活性, TDP-43 磷酸化和ALS 药理学治疗之间的分子联系
… amino acid glutamate found in patients cerebrospinal fluid has led to the hypothesis of …
linking together the two main clinical symptoms of ALS: glutamate-mediated excitotoxicity and TDP…
linking together the two main clinical symptoms of ALS: glutamate-mediated excitotoxicity and TDP…
代谢产物和微营养素在调节肌萎缩侧索硬化中的作用
K Claud, J Sun - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… ALS diagnosis and treatment. From this perspective, we will provide an overview of the
microbiome and metabolites in ALS … -state mice, and is hypothesized to stem from the difference …
microbiome and metabolites in ALS … -state mice, and is hypothesized to stem from the difference …
阿尔茨海默氏病的病理机制和治疗策略
Y Ju, KY Tam - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
… Amyloid cascade hypothesis is the most popular pathological … mechanism of this disease
(Cao et al., 2018). There are numerous … using multi-target drug development for AD treatment. …
(Cao et al., 2018). There are numerous … using multi-target drug development for AD treatment. …
肌萎缩性脊髓侧索硬化的致病机制
Y Hu, W Chen, C Wei, S Jiang, S Li, X Wang… - 中国神经再生研究(英文 …, 2024 - sjzsyj.com.cn
… for the treatment of amyotrophic lateral sclerosis. Studying the … explain ALS pathogenesis:
1) The dying forward hypothesis … Glutamate transport defects correlate with ALS pathogenesis…
1) The dying forward hypothesis … Glutamate transport defects correlate with ALS pathogenesis…
肌萎缩性侧索硬化的当前问题与观点
S Mathis, P Couratier, A Julian, P Corcia… - 中国神经再生研究 …, 2017 - sjzsyj.com.cn
… treatment for ALS: palliative care and symptomatic treatment are … dysregulation of glutamatergic
signaling (through intracellular … This excitotoxic hypothesis has given rise to an extremely …
signaling (through intracellular … This excitotoxic hypothesis has given rise to an extremely …
重新思考神经退行性疾病: 将脂质氧化与中枢神经系统疾病联系起来的神经代谢概念
SS Helgudóttir, AS Mørkholt, J Lichota… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
… into future drug development strategies for neurodegenerative disorders such as ALS, PD, …
prevailing hypothesis on the pathogenesis of these diseases, which remain without a cure. …
prevailing hypothesis on the pathogenesis of these diseases, which remain without a cure. …
NADPH 氧化酶4 (NOX4) 作为神经退行性疾病的生物标志物和治疗靶点
N Boonpraman, SS Yi - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… drug target potential, and paving the path for novel treatment … Research on ALS has shown
that astrocytes with the mutant … Based on the general principles of drug development and …
that astrocytes with the mutant … Based on the general principles of drug development and …
受真菌污染的草和井水以及散发性肌萎缩侧索硬化
PW French, RI Ludowyke, GJ Guillemin - 中国神经再生研究(英文版), 2019 - sjzsyj.com.cn
… Evidence for this hypothesis comes from a variety of sources. … origin of sporadic amyotrophic
lateral sclerosis (ALS), the … and sporadic ALS could lead to novel treatment strategies for …
lateral sclerosis (ALS), the … and sporadic ALS could lead to novel treatment strategies for …
抗氧化化合物对神经退行性变的神经保护作用
R Skouta - 中国神经再生研究(英文版), 2016 - sjzsyj.com.cn
… 24 hrs after the end of glutamate treatment in the CA3 field of … Based on these data, It was
hypothesized that Fer-1 would … Parkinsonian biomarkers (Uehara et al., 2006) which eliminates …
hypothesized that Fer-1 would … Parkinsonian biomarkers (Uehara et al., 2006) which eliminates …
[PDF][PDF] 中药健脾益肺方对EAAT2 表达的影响
李惠珍， 任展能， 李雅青， 杨碧莹… - 中国比较医学杂志, 2019 - zgbjyx.cnjournals.com
… The glutamate hypothesis in ALS: Pathophysiology and drug development [ J ] Curr Med
Chem,2014,21(31):3551-3575. [ 2 ] Hertz L. Intercellular metabolic compartmentation in the …
Chem,2014,21(31):3551-3575. [ 2 ] Hertz L. Intercellular metabolic compartmentation in the …