… Amantadine, an inhibitor of ion channel activity that inhibits viral uncoating, was used as a …
Currently available antiviral drugs target viral protein functions such as M2 ion channel activity …

… therapeutic design and proteins as potential targets of antivirals. Here we give three typical
… of viral membrane fusion and viral ion channel function and the strategies of antiviral drug …

… , with attendant expectations of new, safer drug targets, the promise of which has yet to be
… of drug–receptor interactions, the chemical pharmacology of drugs active at ion channels, …

… also suggests these channels as a therapeutic target, is their … as the activity of Ca2+ ion
channels and glutamate receptors in … The antiviral drug tenofovir, used in the treatment of viral …

… caused by pathogenic avian influenza virus (AIV) have … viruses and the rapid development
of drug discovery screening technology, a new generation of anti-influenza drug targets and …

… cellular stress and are possible targets for the pathophysiology and treatment of … antiviral
molecules (Choi et al., 2018). This could make autophagy detrimental for the host, since viruses …

… been accepted as a common target in their mechanism of action. However, it has been
demonstrated that some antibacterial peptides can reach intracellular targets and other peptides …

… Similarly, inhibition of virus elimination by suppression of … in a murine influenza virus-infected
pneumonia model [6,8]. … domains of target proteins, including protein kinases, ion channels, …

… 目前,解释AMPs作用于细菌膜的机制,有桶板模型(barrel-stave model),环形孔模型(toroidal-pore
model),地毯模型(carpet-like model) 聚合模型(aggregate model).如图3所示(Nguyen等,2011 …

… 最近更新的APD3 根据AMPs 的生物活性可将其分 为20 多个种类, 这些生物活性主要包括抗
细菌,抗病 毒,抗真菌,抗寄生虫,抗人类免疫缺陷病毒(human immunodeficiency virus, HIV)和抗肿瘤…