Base editing: precision chemistry on the genome and transcriptome of living cells
… base editors achieve analogous changes using components that target RNA. Base editors
directly convert one base or base … -dividing cells without generating excess undesired editing …
directly convert one base or base … -dividing cells without generating excess undesired editing …
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker… - Nature Reviews Drug …, 2020 - nature.com
… in living cells — is one of the most recent advances in the field of genome … cells process
base editing intermediates may additionally inform new therapeutic strategies using base editors…
base editing intermediates may additionally inform new therapeutic strategies using base editors…
Base editing of organellar DNA with programmable deaminases
… in living cells. Recently, CRISPR-free, protein-only base editors, such as double-stranded
DNA … toxin A-derived cytosine base editors (DdCBEs) and adenine base editors (ABEs), have …
DNA … toxin A-derived cytosine base editors (DdCBEs) and adenine base editors (ABEs), have …
Therapeutic base editing of human hematopoietic stem cells
… Live cell images were acquired using a Nikon Eclipse Ti inverted microscope. Image
acquisition was performed at room temperature and air in a 24-well plate. Sickled …
acquisition was performed at room temperature and air in a 24-well plate. Sickled …
Base editors: modular tools for the introduction of point mutations in living cells
M Evanoff, AC Komor - Emerging topics in life sciences, 2019 - portlandpress.com
… With dozens of base editors now reported, it is … of base editors, each with its own unique
properties and potential uses. In this perspective, we describe currently available base editors, …
properties and potential uses. In this perspective, we describe currently available base editors, …
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
… Adenine base editors (ABEs) convert targeted A•T base pairs to G•C in living cells without
requiring DSBs or donor DNA templates, and with minimal formation of indels 2 . In SCD, the …
requiring DSBs or donor DNA templates, and with minimal formation of indels 2 . In SCD, the …
Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells.
HA Rees, DR Liu - Nature Reviews. Genetics, 2018 - europepmc.org
The originally published article contained errors in reference numbering throughout table 1 (DNA
base editors and their approximate editing windows) due to the unintended …
base editors and their approximate editing windows) due to the unintended …
GO: a functional reporter system to identify and enrich base editing activity
… Development of a specific cytosine base editing reporter: Cy GO To detect cytosine BE
events in real time in living cells, we sought to create a reporter that would become activated …
events in real time in living cells, we sought to create a reporter that would become activated …
Bioorthogonally activatable base editing for on-demand pyroptosis
WSC Ngai, S Yang, X Zeng, Y Liu, F Lin… - Journal of the …, 2022 - ACS Publications
… was triggered through Me 2 Tz addition and the editing efficiency was computed as the C:…
base editing activities of BaseBAC over a 48 h time-course. We observed distinct C-to-T editing …
base editing activities of BaseBAC over a 48 h time-course. We observed distinct C-to-T editing …
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
… Base editing induces single-nucleotide changes in the DNA of living cells using a fusion
protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase…
protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine deaminase…
相关搜索
- base editing stem cells
- targeted a-to g base editing
- base editing programmable deaminases
- base editing cas9 cytidine
- base editing human mitochondrial dna
- base editing precision chemistry
- multiple cell types base editing outcomes
- base editing somatic cells
- base editing in human cells
- crispr cas mediated base editing
- base editing activity
- efficient base editing
- base editing tools
- crispr base editing
- adenine base editing
- live cell visualization