Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
… Based on the overlap of significant gene expression changes with established HAND2 DNA
… putative HAND2-dependent endocardial transcriptional enhancers. We selected five genes …
… putative HAND2-dependent endocardial transcriptional enhancers. We selected five genes …
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects
JW Vincentz, RM Barnes… - Birth Defects Research Part …, 2011 - Wiley Online Library
… These observations indicate that in zebrafish, hand2 regulates cardiac chamber-specific
gene expression and has a more general role in the early morphogenesis and differentiation of …
gene expression and has a more general role in the early morphogenesis and differentiation of …
Hand factors in cardiac development
RM George, AB Firulli - The Anatomical Record, 2019 - Wiley Online Library
… be critical for cardiac morphogenesis including, trabeculation… heart and each cell lineage
relies on a finely tuned gene … Hand1 and Hand2 play key roles within the gene regulatory …
relies on a finely tuned gene … Hand1 and Hand2 play key roles within the gene regulatory …
[HTML][HTML] Hand2 regulates epithelial formation during myocardial differentiation
LA Trinh, D Yelon, DYR Stainier - Current biology, 2005 - cell.com
… of the myocardial epithelium and that driving myocardial gene expression. Specifically,
we analyzed the role of the myocardial differentiation gene, hand2, in myocardial epithelia …
we analyzed the role of the myocardial differentiation gene, hand2, in myocardial epithelia …
The role of Hand2 during cardiac fusion: Importance of the environment for heart morphogenesis
ZV Garavito-Aguilar - 2010 - search.proquest.com
… component of the Hand2 pathway that mediates cardiac morphogenesis. Although hand2 is
expressed … Here, we provide the first genetic link between Hand2 and a downstream effector …
expressed … Here, we provide the first genetic link between Hand2 and a downstream effector …
[HTML][HTML] Hand2 function in second heart field progenitors is essential for cardiogenesis
… utilizing a variety of unique Cre-driver mouse lines, we have revealed some tissue-specific
roles of the Hand2 gene during the development of early cardiac progenitors. More …
roles of the Hand2 gene during the development of early cardiac progenitors. More …
Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development
K Togi, Y Yoshida, H Matsumae, Y Nakashima… - Biochemical and …, 2006 - Elsevier
… Here, we found that the other Hand gene, Hand2, regulated expansion, trabeculation, and
… of Hand2 during cardiac morphogenesis, we created transgenic mice expressing Hand2 …
… of Hand2 during cardiac morphogenesis, we created transgenic mice expressing Hand2 …
[PDF][PDF] HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development
F Laurent, A Girdziusaite, J Gamart, I Barozzi… - Cell reports, 2017 - cell.com
… their expression are associated with HAND2 ChIP-seq peaks (… of these genes are associated
with at least one HAND2 ChIP-… of genes functioning in mouse OFT and RV morphogenesis …
with at least one HAND2 ChIP-… of genes functioning in mouse OFT and RV morphogenesis …
[PDF][PDF] Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium
NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli… - Cell reports, 2014 - cell.com
… that endocardial Hand2 plays a crucial role in myocardial morphogenesis. Myocardial trabe…
VegfA is the most differentially regulated gene that we observe, while VegfR2, VegfR3, and …
VegfA is the most differentially regulated gene that we observe, while VegfR2, VegfR3, and …
HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis
M Xia, W Luo, H Jin, Z Yang - Development, 2019 - journals.biologists.com
… To better investigate the potential role of these genes in OFT morphogenesis, we
generated specific monoclonal antibodies (in collaboration with Abcam), resulting in a …
generated specific monoclonal antibodies (in collaboration with Abcam), resulting in a …
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