… reductions in the plasma concentrations of OATP1B1 and CYP3A4 bisubstrates. As … OATP1B1
and OATP1B3, we should be aware of DDIs caused by the inhibition of these transporters…

… inhibitors, of which 22 had not been identified previously as interacting with the
OATP1B1 transporter. To our knowledge, this is the most comprehensive investigation of …

… OATP1B1 appears to be the most important, and variation of its transport activity owing to …
Besides being a substrate of OATP1B1, pravastatin and rosuvastatin are transported by …

… of other transporters such as … OATP1B1 is a responsible transporter for the pitavastatin
uptake by two kinds of approaches: the comparison of the expression level of each transporter in …

… drug-drug interactions as many drugs in this class are known or suspected to potently inhibit
the hepatic uptake transporters OATP1B1 … inhibit the function of OATP1B1 and/or OATP1B3 …

… the contribution of this transporter to the absorption and drug-drug interaction potential of
drugs. … Although OATP1B1 and OATP1B3 mediate the hepatic uptake of various known …

… the hepatic OATP family members OATP1B1, OATP1B3, and … drug-drug interactions, and
on functional consequences of genetic variations in genes encoding these uptake transporters. …

… affecting them will result in pharmacokinetic drug interactions. This article focuses on the
drug interactions of meglitinides involving CYP enzymes and OATP1B1 transporter. To prevent …

… is a substrate of the efflux transporter BCRP in vitro and that the drug's AUC increased 1.72-fold
(with … Pharmacogenetic analysis has established that the OATP1B1 transporter (1) has a …

… The liver uptake transporter OATP1B1 has been recognized by drug agencies as a
determinant of drug–drug interactions. Nevertheless, labeling of OATP1B1 interactions appears …