[HTML][HTML] Pharmacokinetic and pharmacodynamic responses to clopidogrel: evidences and perspectives
… poor clopidogrel response have not yet been fully elucidated. In this review, we systematically
summarized numerous factors affecting the pharmacodynamics and pharmacokinetics of …
summarized numerous factors affecting the pharmacodynamics and pharmacokinetics of …
The integration of pharmacokinetics and pharmacodynamics: understanding dose-response
SM Abdel-Rahman, RE Kauffman - Annu. Rev. Pharmacol …, 2004 - annualreviews.org
Pharmacokinetic (PK) and pharmacodynamic (PD) studies have proven to be powerful and
instructive tools, particularly in elucidating important aspects of human pharmacology. …
instructive tools, particularly in elucidating important aspects of human pharmacology. …
What have we learned from pharmacokinetic and pharmacodynamic theories?
JJ Schentag, KK Gilliland… - Clinical Infectious …, 2001 - academic.oup.com
… We have learned that newer indexes of pharmacodynamic response, such as AUIC, seem
… Ultimately, if we utilize these pharmacokinetic and pharmacodynamic principles correctly, …
… Ultimately, if we utilize these pharmacokinetic and pharmacodynamic principles correctly, …
Pharmacokinetic–pharmacodynamic modelling of behavioural responses
OE Della Paschoa, MR Kruk, M Danhof - Neuroscience & Biobehavioral …, 1998 - Elsevier
… the role of pharmacokinetics or even homeostatic regulation in the pharmacodynamic
response. … –effect relationship and accurate individual pharmacodynamic estimates [eg (E max ) …
response. … –effect relationship and accurate individual pharmacodynamic estimates [eg (E max ) …
Dose response: Pharmacokinetic–pharmacodynamic approach
N Holford - Dose Finding in Drug Development, 2006 - Springer
… distinguished the pharmacokinetic and pharmacodynamic sources of variability in response
to a dose and offers practical advice for implementation of exposure response analysis. …
to a dose and offers practical advice for implementation of exposure response analysis. …
Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapy
… the changes in the pharmacokinetics of drugs caused … pharmacokinetics and
pharmacodynamics of cytotoxic agents. We argue that, overall, these factors identify inflammatory …
pharmacodynamics of cytotoxic agents. We argue that, overall, these factors identify inflammatory …
Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d‐tubocurarine
LB Sheiner, DR Stanski, S Vozeh… - Clinical …, 1979 - Wiley Online Library
… pharmacodynamics: Application to d-tubocurarine We propose a model of drug pharmacodynamic
response that when integrated with a pharmacokinetic model allows characterization …
response that when integrated with a pharmacokinetic model allows characterization …
[HTML][HTML] Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
JT Brandt, SL Close, SJ Iturria, CD Payne… - Journal of Thrombosis …, 2007 - Elsevier
… A lower pharmacodynamic response has been linked to a … that a reduced pharmacodynamic
response to clopidogrel is … prasugrel pharmacokinetics or pharmacodynamic response. …
response to clopidogrel is … prasugrel pharmacokinetics or pharmacodynamic response. …
Pharmacokinetic–pharmacodynamic modelling: history and perspectives
C Csajka, D Verotta - … of pharmacokinetics and pharmacodynamics, 2006 - Springer
… of pharmacokinetic–pharmacodynamic (PK/PD) modelling has made many advances from
the basic concept of the dose–response … of the concentration–response relationship from the …
the basic concept of the dose–response … of the concentration–response relationship from the …
Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapy
JH Lin - Current drug metabolism, 2007 - ingentaconnect.com
… not only by pharmacokinetic processes, but also by pharmacodynamic processes. Therefore,
the variability in drug response is a result of the variability in either pharmacokinetic or …
the variability in drug response is a result of the variability in either pharmacokinetic or …
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