The site of protein folding and maturation for the majority of proteins that are secreted,
localized to the plasma membrane or targeted to endomembrane compartments is the …

The ER quality control system targets misfolded proteins for degradation through the ER‐
associated degradation (ERAD) process. EDEM, a putative Type II membrane protein is …

The endoplasmic reticulum (ER) must contend with a large protein flux, which is especially
notable in cells dedicated to secreting hormone‐regulated gene products. Because of the …

The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and
where stringent quality-control systems ensure that only correctly folded proteins are sent to …

Glycoprotein folding and degradation in the endoplasmic reticulum (ER) is mediated by the
ER quality control system. Mannose trimming plays an important role by forming specific N …

Endoplasmic reticulum (ER) quality control (ERQC) of protein folding may be divided into
three categories, depending on the property that is evaluated:(1) assessment of the …

ABSTRACT A quality control system in the endoplasmic reticulum (ER) efficiently
discriminates polypeptides that are in the process of productive folding from conformers that …

The quality control (QC) system of the endoplasmic reticulum (ER) is an important
monitoring mechanism in the protein maturation process, which ensures export of properly …