神经元重编程治疗脊髓损伤

X Chen, H Li - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
Spinal cord injury represents a devastating central nervous system injury that could impair
the mobility and sensory function of afflicted patients. The hallmarks of spinal cord injury …

[HTML][HTML] Neuronal reprogramming in treating spinal cord injury

X Chen, H Li - Neural regeneration research, 2022 - journals.lww.com
Spinal cord injury represents a devastating central nervous system injury that could impair
the mobility and sensory function of afflicted patients. The hallmarks of spinal cord injury …

[HTML][HTML] Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

R Yang, J Pan, Y Wang, P Xia, M Tai… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) is a serious neurological trauma that is challenging to treat. After
SCI, many neurons in the injured area die due to necrosis or apoptosis, and astrocytes …

[HTML][HTML] A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation

YM Fang, WC Chen, WJ Zheng, YS Yang… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Spinal cord injury causes varying degrees of motor and sensory function loss. However,
there are no effective treatments for spinal cord repair following an injury. Moreover …

In vivo cell fate reprogramming for spinal cord repair

W Tai, CL Zhang - Current Opinion in Genetics & Development, 2023 - Elsevier
Spinal cord injury (SCI) can lead to the loss of motor, sensory, or autonomic function due to
neuronal death. Unfortunately, the adult mammalian spinal cord has limited intrinsic …

Therapeutical strategies for spinal cord injury and a promising autologous astrocyte-based therapy using efficient reprogramming techniques

H Yang, C Liu, CY Wang, Q Zhang, J An, L Zhang… - Molecular …, 2016 - Springer
Spinal cord injury (SCI) is a traumatic event resulting in disturbances to normal sensory,
motor, or autonomic functions, which ultimately impacts a patient's physical, psychological …

[HTML][HTML] Improving Efficiency of Direct Pro-Neural Reprogramming: Much-Needed Aid for Neuroregeneration in Spinal Cord Injury

DA Chudakova, EM Samoilova, VP Chekhonin… - Cells, 2023 - mdpi.com
Spinal cord injury (SCI) is a medical condition affecting~ 2.5–4 million people worldwide.
The conventional therapy for SCI fails to restore the lost spinal cord functions; thus, novel …

[HTML][HTML] Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

B Puls, Y Ding, F Zhang, M Pan, Z Lei, Z Pei… - Frontiers in cell and …, 2020 - frontiersin.org
Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially
because the injury-induced neuronal loss cannot be easily replenished through …

[HTML][HTML] Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Reversion of injured adult neurons to an embryonic state by grafts of neural progenitor cells after spinal cord injury

L Cao, Y Wang, Z Huang - Neuroscience Bulletin, 2021 - Springer
Spinal cord injury (SCI) is a severe condition characterized by neurological dysfunction,
dependence, respiratory failure, psychological morbidities, and an increased mortality rate …