Precise tuning of gene expression, accomplished by regulatory networks of transcription
factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development …

Precise tuning of gene expression, accomplished by regulatory networks of transcription
factors, epigenetic modifiers, and microRNAs, is crucial for the proper neural development …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Glioblastoma (GBM) continues to be the most devastating primary brain malignancy. Despite
significant advancements in understanding basic GBM biology and enormous efforts in …

SOX2 has a crucial role in maintaining the self-renewing and pluripotent or multipotent stem
cell state. Dysregulation of SOX2 expression and activity in this context has severe …

Long noncoding RNAs (lncRNAs) are emerging as key regulators of crucial cellular
processes. However, the molecular mechanisms of many lncRNA functions remain …

During development of myelin‐forming oligodendrocytes in the central nervous system the
two closely related transcription factors Sox9 and Sox10 play essential roles that are partly …

Long noncoding RNAs (lncRNAs) are abundant in the mammalian transcriptome, and many
are specifically expressed in the brain. We have identified a group of lncRNAs, including …

转录因子SOX9 属于SOX 家族中SOXE 亚类, 目前已有大量文献证实其表达与神经胶质瘤有关.
神经胶质瘤是最常见的恶性脑肿瘤, 而高级别胶质瘤患者的预后极差, 因此研究神经胶质瘤发病 …

Oligodendrocytes wrap and physically shield axons of the central nervous system with
myelin sheaths, resulting in rapid signal transduction and accurate neuronal function. The …